- Home
- A-Z Publications
- CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)
- Previous Issues
- Volume 5, Issue 1, 2006
CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders) - Volume 5, Issue 1, 2006
Volume 5, Issue 1, 2006
-
-
Editorial [Hot Topic: Dopaminergic Neurotransmission (Guest Editor: Remco H.S. Westerink)]
More LessDecades ago, in 1959, dopamine was found to be an essential neurotransmitter. In the years that followed, dopaminergic neurotransmission turned out to be critical for normal motor-, motivational- and reward-related functions. Nowadays it is known that dopaminergic signaling is not restricted to point-to-point synaptic contacts, but also involves volume transmission, which requires synaptic spillover of released dopamine to rea Read More
-
-
-
Editorial [Hot Topic: Dopaminergic Neurotransmission (Guest Editor: Remco H.S. Westerink)]
More LessDecades ago, in 1959, dopamine was found to be an essential neurotransmitter. In the years that followed, dopaminergic neurotransmission turned out to be critical for normal motor-, motivational- and reward-related functions. Nowadays it is known that dopaminergic signaling is not restricted to point-to-point synaptic contacts, but also involves volume transmission, which requires synaptic spillover of released dopamine to rea Read More
-
-
-
Dopamine Receptor Pharmacology: Interactions with Serotonin Receptors and Significance for the Aetiology and Treatment of Schizophrenia
Authors: T. R. Werkman, J. C. Glennon, W. J. Wadman and A. C. McCrearyThe classification of dopamine receptors proposed more than two decades ago remains valid today. Based on biochemical and pharmaceutical properties two main classes of dopamine receptors can be distuinguished: D1-like (D1, D5) and D2-like (D2, D3, and D4) dopamine receptors. Dopamine receptors belong to the class of G protein-coupled receptors and signal to a wide range of membrane bound and intracellular Read More
-
-
-
Dopamine Receptor Pharmacology: Interactions with Serotonin Receptors and Significance for the Aetiology and Treatment of Schizophrenia
Authors: T. R. Werkman, J. C. Glennon, W. J. Wadman and A. C. McCrearyThe classification of dopamine receptors proposed more than two decades ago remains valid today. Based on biochemical and pharmaceutical properties two main classes of dopamine receptors can be distuinguished: D1-like (D1, D5) and D2-like (D2, D3, and D4) dopamine receptors. Dopamine receptors belong to the class of G protein-coupled receptors and signal to a wide range of membrane bound and intracellular Read More
-
-
-
The Dopamine D3 Receptor: A Therapeutic Target for the Treatment of Neuropsychiatric Disorders
Authors: P. Sokoloff, J. Diaz, B. L. Foll, O. Guillin, L. Leriche, E. Bezard and C. GrossThe role of the D3 receptor has remained largely elusive before the development of selective research tools, such as selective radioligands, antibodies, various highly specific pharmacological agents and knock-out mice. The data collected so far with these tools have removed some of the uncertainties regarding the functions mediated by the D3 receptor. The D3 receptor is an autoreceptor that controls the phasic, but Read More
-
-
-
The Dopamine D3 Receptor: A Therapeutic Target for the Treatment of Neuropsychiatric Disorders
Authors: P. Sokoloff, J. Diaz, B. L. Foll, O. Guillin, L. Leriche, E. Bezard and C. GrossThe role of the D3 receptor has remained largely elusive before the development of selective research tools, such as selective radioligands, antibodies, various highly specific pharmacological agents and knock-out mice. The data collected so far with these tools have removed some of the uncertainties regarding the functions mediated by the D3 receptor. The D3 receptor is an autoreceptor that controls the phasic, but Read More
-
-
-
Molecular Biology, Pharmacology and Functional Role of the Plasma Membrane Dopamine Transporter
Authors: Tatyana D. Sotnikova, Jean-Martin Beaulieu, Raul R. Gainetdinov and Marc G. CaronThe plasma membrane dopamine transporter (DAT) tightly regulates the extracellular concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring DA projections thereby providing an effective way to regulate synaptic and extrasynaptic DA levels. This transporter is a primary target of many potent psychotropic drugs and neurotoxins, such as c Read More
-
-
-
Molecular Biology, Pharmacology and Functional Role of the Plasma Membrane Dopamine Transporter
Authors: Tatyana D. Sotnikova, Jean-Martin Beaulieu, Raul R. Gainetdinov and Marc G. CaronThe plasma membrane dopamine transporter (DAT) tightly regulates the extracellular concentrations of dopamine (DA) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring DA projections thereby providing an effective way to regulate synaptic and extrasynaptic DA levels. This transporter is a primary target of many potent psychotropic drugs and neurotoxins, such as c Read More
-
-
-
Targeting Exocytosis: Ins and Outs of the Modulation of Quantal Dopamine Release
More LessDopaminergic neurotransmission is mediated by the vesicular release of dopamine (DA), i.e. DA exocytosis. DA exocytosis and its modulation are generally believed to affect neuronal communication, development, maintenance and survival, and contribute to extracellular DA levels in the brain. As a result, DA exocytosis likely plays an important role in several neurological and psychiatric disorders, like Parkinson's disease ( Read More
-
-
-
Targeting Exocytosis: Ins and Outs of the Modulation of Quantal Dopamine Release
More LessDopaminergic neurotransmission is mediated by the vesicular release of dopamine (DA), i.e. DA exocytosis. DA exocytosis and its modulation are generally believed to affect neuronal communication, development, maintenance and survival, and contribute to extracellular DA levels in the brain. As a result, DA exocytosis likely plays an important role in several neurological and psychiatric disorders, like Parkinson's disease ( Read More
-
-
-
Excitability of Dopamine Neurons: Modulation and Physiological Consequences
Authors: M. Marinelli, C. N. Rudick, X- T. Hu and F. J. WhiteThis aim of this chapter is to review literature on the excitability and function of dopamine neurons that originate in the midbrain and project to cortico-limbic and motor structures (A9 and A10 dopamine pathways). Electrophysiological studies on rodent or non-human primates have shown that these dopamine neurons are silent or spontaneously active. The spontaneously active neurons show slow regular firing, slow irregul Read More
-
-
-
Excitability of Dopamine Neurons: Modulation and Physiological Consequences
Authors: M. Marinelli, C. N. Rudick, X- T. Hu and F. J. WhiteThis aim of this chapter is to review literature on the excitability and function of dopamine neurons that originate in the midbrain and project to cortico-limbic and motor structures (A9 and A10 dopamine pathways). Electrophysiological studies on rodent or non-human primates have shown that these dopamine neurons are silent or spontaneously active. The spontaneously active neurons show slow regular firing, slow irregul Read More
-
-
-
Phasic Dopamine Signaling During Behavior, Reward, and Disease States
Authors: M. L.A.V. Heien and R. M. WightmanThe neurotransmitter dopamine is important in reward processing, however its precise modulatory role is still being investigated. Carbon-fiber microelectrodes can be used to monitor dopamine on a subsecond time scale in the striatum and nucleus accumbens of rats during behavior, and this approach is providing new insights into the mechanisms that control its extracellular concentration as well as the conditions under w Read More
-
-
-
Phasic Dopamine Signaling During Behavior, Reward, and Disease States
Authors: M. L.A.V. Heien and R. M. WightmanThe neurotransmitter dopamine is important in reward processing, however its precise modulatory role is still being investigated. Carbon-fiber microelectrodes can be used to monitor dopamine on a subsecond time scale in the striatum and nucleus accumbens of rats during behavior, and this approach is providing new insights into the mechanisms that control its extracellular concentration as well as the conditions under w Read More
-
-
-
Dopamine and the Diseased Brain
Authors: T. Kienast and A. HeinzDysfunction of central dopaminergic neurotransmission has been implicated in a series of neuropsychiatric disorders, including Tourette's syndrome, schizophrenia, and drug and alcohol dependence. The behavioral and psychopathological manifestations of central dopaminergic dysfunction differ depending on the site of their neurobiological correlate. These sites may be found in the dorsal or ventral striatum, bu Read More
-
-
-
Dopamine and the Diseased Brain
Authors: T. Kienast and A. HeinzDysfunction of central dopaminergic neurotransmission has been implicated in a series of neuropsychiatric disorders, including Tourette's syndrome, schizophrenia, and drug and alcohol dependence. The behavioral and psychopathological manifestations of central dopaminergic dysfunction differ depending on the site of their neurobiological correlate. These sites may be found in the dorsal or ventral striatum, bu Read More
-
Volumes & issues
-
Volume 24 (2025)
-
Volume 23 (2024)
-
Volume 22 (2023)
-
Volume 21 (2022)
-
Volume 20 (2021)
-
Volume 19 (2020)
-
Volume 18 (2019)
-
Volume 17 (2018)
-
Volume 16 (2017)
-
Volume 15 (2016)
-
Volume 14 (2015)
-
Volume 13 (2014)
-
Volume 12 (2013)
-
Volume 11 (2012)
-
Volume 10 (2011)
-
Volume 9 (2010)
-
Volume 8 (2009)
-
Volume 7 (2008)
-
Volume 6 (2007)
-
Volume 5 (2006)
Most Read This Month
Article
content/journals/cnsnddt
Journal
10
5
false
en

Most Cited Most Cited RSS feed
-
-
A Retrospective, Multi-Center Cohort Study Evaluating the Severity- Related Effects of Cerebrolysin Treatment on Clinical Outcomes in Traumatic Brain Injury
Authors: Dafin F. Muresanu, Alexandru V. Ciurea, Radu M. Gorgan, Eva Gheorghita, Stefan I. Florian, Horatiu Stan, Alin Blaga, Nicolai Ianovici, Stefan M. Iencean, Dana Turliuc, Horia B. Davidescu, Cornel Mihalache, Felix M. Brehar, Anca . S. Mihaescu, Dinu C. Mardare, Aurelian Anghelescu, Carmen Chiparus, Magdalena Lapadat, Viorel Pruna, Dumitru Mohan, Constantin Costea, Daniel Costea, Claudiu Palade, Narcisa Bucur, Jesus Figueroa and Anton Alvarez
-
-
-
- More Less