CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders) - Volume 20, Issue 8, 2021

Background: A large number of individuals today use herbs as a drug alongside medicine and non-physician recommended medications, as herbs are thought to be natural and safe. However, there are many herbs that can potentially interact with other drugs, causing hazardous effects and/or diminished therapeutic effects of other prescriptions. Objective: It is ought to be comprehended that herbal drugs contain multiple activ Read More

Conventionally, cardiac biomarkers are recognized as an essential tool to investigate the presence or progression of various cardiovascular diseases. However, in recent years, data from several clinical trials have successfully sorted out the utility of cardiac biomarkers in diseases that are not primarily regarded as “cardiac diseases,” especially neurological diseases. Results of freshly published trials have endorsed the Read More

Neurodegenerative diseases represent one of the most important public health problems and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the elderly. However, natural products have a significant function in the avoidance of disease by boosting health in humans as well as animals. These natural products have been scientifically acknowledged to have a range of biological charact Read More

Dementia is a diverse category of chronic and progressive disorder, which is commonly associated with a loss of memory, difficulty in judgment, impaired language, cognitive impairment, and various other symptoms that affect a person’s daily routine life and social life. Dementia affects about 50 million people around the globe. Dementia exists in varied forms and is associated with various neurodegenerative disorders. Read More

Alzheimer’s Disease (AD), characterized by abnormally phosphorylated tau, Paired Helical Filaments (PHFs), Neurofibrillary Tangles (NFTs), deregulated mammalian Target Of Rapamycin (mTOR), and Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirec Read More

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by sleep, behavioral, memory, and cognitive deteriorations. Sleep disturbance (SD) is a major disease burden in AD, which has a reciprocal relationship with AD pathophysiology. It aggravates memory, behavioral, and cognitive complications in AD. Different studies have found that melatonin hormone levels reduce even in the pre-clinica Read More

Background: Lack of sleep generates many disorders and bruxism is one of them. It has affected almost 31% of the world population. Aim: The purpose of this paper is to determine the volume of the research conducted on bruxism and to create a database. We aimed to highlight critical issues for further research commitments and communications. This paper designs a comprehensive and very perception-based picture Read More