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2000
Volume 21, Issue 5
  • ISSN: 1567-2026
  • E-ISSN: 1875-5739

Abstract

Background

Plasma osteoprotegerin (OPG) has been linked to poor prognosis following stroke, but its impact on post-stroke cognitive impairment (PSCI) is unknown. The purpose of our work was to analyze the relationship of OPG with PSCI.

Methods

Our study included 613 ischemic stroke subjects with plasma OPG levels. We used the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to assess PSCI. PSCI was defined as MMSE score <25 or MoCA score <23.

Results

As assessed by the MMSE score, the adjusted odds ratio for PSCI in the highest OPG tertile was 1.77, with a 95% confidence interval of 1.09 to 2.89 (=0.021), compared to that in the lowest tertile. We observed a positive linear relationship of plasma OPG levels with 3-month PSCI ( for linearity=0.046). Incorporating plasma OPG into conventional risk factors enhanced PSCI risk reclassification (all <0.05). Consistent results were discovered when PSCI was evaluated using the MoCA score.

Conclusion

High plasma OPG levels were related to an elevated risk of 3-month PSCI, indicating that OPG might be an effective biomarker for predicting PSCI.

© 2024 Bentham Science Publishers
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2025-01-29
2025-08-27

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Plasma Osteoprotegerin and Cognitive Impairment after Ischemic Stroke
Curr Neurovasc Res 21, 545 (2024); https://doi.org/10.2174/0115672026368528250113080256
/content/journals/cnr/10.2174/0115672026368528250113080256
/content/journals/cnr/10.2174/0115672026368528250113080256
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  • Article Type:     Research Article
Keyword(s): biomarker; cognitive impairment; Ischemic stroke; mini-mental state examination; osteoprotegerin; risk factors

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