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Volume 21, Issue 2
  • ISSN: 1567-2026
  • E-ISSN: 1875-5739

Abstract

Objective

Early Neurological Deterioration (END) is one of the complications in Acute ischemic stroke (AIS) and relates to prognosis. However the reason why it occurs is still unclear. Our study is to investigate if CT perfusion (CTP) can predict END in patients with Minor Stroke and Large Vessel Occlusion after Intravenous Thrombolysis (IVT).

Methods

Patients who underwent IVT with Large Vessel Occlusion were enrolled continuously from January 2021 to August 2023. After evaluating the National Institutes of Health Stroke Scale (NIHSS) score, they were divided into the END group (n=21) and the Non-END group (n=20). Multivariate logistic regression analysis was performed to explore the factors of END. Receiver-operating characteristic (ROC) curve analysis was also used to assess the discriminative ability of CTP in predicting END.

Results

A total of 41 patients (mean age, 62.34 ± 10.82 years, 27 male) were finally included in the analysis; 21 patients had END, and 9 patients underwent Endovascular thrombectomy (EVT). Multivariate logistic regression analysis indicated that rCBV (OR=0.081, 95%CI=0.009-0.721, = 0.024) and admission-NIHSS (OR=1.990, 95%CI=1.049-3.772, = 0.035) were significantly associated with END. The area under the curve (AUC) of rCBV and NIHSS to discriminate END were 0.708 and 0.758. We found patients with END had a higher modified Rankin Scale (mRS) in 3 months.

Conclusions

The rCBV and NIHSS were associated with post-thrombolysis END and may become reliable markers to predicate END. END might predict a poor 3-month functional outcome.

© 2024 Bentham Science Publishers
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2024-04-02
2025-01-24

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Neuroimaging Marker-CT Perfusion of Early Neurological Deterioration in Patients with Minor Stroke and Large Vessel Occlusion after Intravenous Thrombolysis
Curr Neurovasc Res 21, 198 (2024); https://doi.org/10.2174/0115672026306424240319101049
/content/journals/cnr/10.2174/0115672026306424240319101049
/content/journals/cnr/10.2174/0115672026306424240319101049
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  • Article Type:     Research Article
Keyword(s): CT perfusion; early neurological deterioration; intravenous thrombolysis; Intravenous thrombolysis; minor stroke; NIHSS

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