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Volume 21, Issue 2
  • ISSN: 1567-2026
  • E-ISSN: 1875-5739

Abstract

Background

Research has linked enlarged perivascular spaces (EPVS) to cerebral venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear whether this association exists in recent small subcortical infarct (RSSI) patients.

Objective

This study aimed to investigate the correlation between EPVS and CVR in patients with RSSI.

Methods

This study included 297 patients, selected from patients with RSSI in the lenticulostriate artery admitted to the Department of Neurology of the First Affiliated Hospital of Zhengzhou University. CVR was assessed by time-of-flight magnetic resonance angiography (TOF-MRA). The relationship between EPVS and CVR was studied using multiple logistic regression analysis.

Results

This study included patients with an average age of 59.84±12.27 years, including 201 males (67.7%). CVR was observed in 40 (13.5%) patients. Compared to the group without CVR, the proportions of male patients and patients with a history of smoking and drinking were higher in the CVR group. The proportions of high-grade EPVS in the centrum semiovale region [23 cases (57.5%) . 108 cases (42.0%), =0.067] and the basal ganglia region [30 cases (75.0%) . 133 cases (51.8%), =0.006] were higher in the CVR group. After multiple logistic regression analysis, high-grade EPVS in the basal ganglia region was still associated with CVR (OR, 2.68; 95% CI, 1.22-5.87; =0.014).

Conclusion

In the population with RSSI, EPVS in basal ganglia is significantly associated with CVR, suggesting a close relationship between venous dysfunction and the formation of EPVS.

© 2024 Bentham Science Publishers
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2024-02-07
2025-01-24

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/content/journals/cnr/10.2174/0115672026299546240130092550
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Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral Venous Reflux in Patients with Recent Small Subcortical Infarction
Curr Neurovasc Res 21, 123 (2024); https://doi.org/10.2174/0115672026299546240130092550
/content/journals/cnr/10.2174/0115672026299546240130092550
/content/journals/cnr/10.2174/0115672026299546240130092550
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  • Article Type:     Research Article
Keyword(s): basal ganglia; cerebral small vessel disease; cerebral venous reflux; lenticulostriate artery territory; perivascular space; Recent small subcortical infarction

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