Greener Synthesis of Potential Anti-bacterial Pyrimidin-2(1H)-one Derivatives using Recyclable Nanocatalyst, Fe3O4@SiPr@vanillin@TGA

Background: Dihydropyrimidinones are an essential component of heterocycles due to their useful attributes, such as calcium channel blockers, anti-inflammatory agents, anti-neoplastic agents, anti-bacterial agents, anti-hypertensives, , and, anti-virals. Objective: Synthesis of Fe3O4@SiPr@vanillin@TGA MNPs and their structure and morphology determination by FT-IR, VSM, EDX, XRD, TEM, FE-SEM, Zeta potential, and TGA. Methods: A synthetic mixture of aldehydes, acetophenone, urea, H2O and Fe3O4@SiPr@ vanillin@ TGA MNPs, were stirred at room temperature to establish the appropriate and optimum reaction time. Results: An efficient and greener method for the synthesis of arylpyrimidinones using Fe3O4@SiPr@vanillin@TGA MNPs in aqueous medium has been accomplished. Conclusion: Higher yields, simpler handling, ease of separation and recycling of the magnetic catalysts, and following the green chemistry tenets for waste minimization and exploitation of abundant natural materials are some of the key features of this process. The anti-bacterial activity of compounds 4a-n and 6a-e were evaluated, and all four bacteria studied were affected by the synthesized compounds.