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image of Scaled-up Processes for the Preparation of Enhanced Antibacterial ZnO-Menthol, ZnO-Chitosan, and ZnO-Triclosan Flake/Spine-like Nanocomposites, and their Biocompatibility and Toxicity Studies

Abstract

Introduction

Nanomaterials, especially their biocompatibilities and toxicities, have not been studied and their integration in real applications is still limited.

Method

This paper addresses this gap by focusing on the development of antibacterial nanomaterials by combining flake/spinal ZnO nanostructures with organic antibacterial agents (menthol, chitosan, and triclosan). We systematically study their biocompatibility and toxicity, intending to apply them practically on fabric surfaces.

Result

Based on the known photocatalytic and antibacterial properties of ZnO, our hypothesis suggests that the unique flake/spine ZnO nanostructures can further improve the antibacterial efficacy through induced mechanistic approaches. The synergistic effect achieved by combining ZnO with menthol, chitosan, and triclosan improves the overall bactericidal ability. XRD, XRF, FTIR, SEM, and UV-visible spectroscopy are used to characterize the nanocomposites. The antibacterial properties of the modified fabrics are tested using standard spread plate techniques. Biocompatibility and toxicity studies using a mouse model provide a comprehensive picture of the safety profile.

Conclusion

This work advances the understanding of antibacterial nanomaterials, and paves the way for their wider manufacturing and practical use in textiles, meeting the industrial needs of antimicrobial clothing and wound dressings.

© 2024 Bentham Science Publishers
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2024-11-11
2025-02-15

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/content/journals/cnano/10.2174/0115734137325025241031151832
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Scaled-up Processes for the Preparation of Enhanced Antibacterial ZnO-Menthol, ZnO-Chitosan, and ZnO-Triclosan Flake/Spine-like Nanocomposites, and their Biocompatibility and Toxicity Studies
Bentham Science Publishers ; https://doi.org/10.2174/0115734137325025241031151832
/content/journals/cnano/10.2174/0115734137325025241031151832
/content/journals/cnano/10.2174/0115734137325025241031151832
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  • Article Type:     Research Article
Keywords: triclosan ; toxicity ; textile applications ; zinc oxide nanostructures ; fabric manufacturing ; scaled-up processes ; biocompatibility ; menthol ; chitosan ; Antibacterial nanomaterials

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