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Volume 23, Issue 5
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Background

Age-related neurodegenerative diseases (NDs) pose a formidable challenge to healthcare systems worldwide due to their complex pathogenesis, significant morbidity, and mortality.

Scope and Approach

This comprehensive review aims to elucidate the central role of the microbiota-gut-brain axis (MGBA) in ND pathogenesis. Specifically, it delves into the perturbations within the gut microbiota and its metabolomic landscape, as well as the structural and functional transformations of the gastrointestinal and blood-brain barrier interfaces in ND patients. Additionally, it provides a comprehensive overview of the recent advancements in medicinal and dietary interventions tailored to modulate the MGBA for ND therapy.

Conclusion

Accumulating evidence underscores the pivotal role of the gut microbiota in ND pathogenesis through the MGBA. Dysbiosis of the gut microbiota and associated metabolites instigate structural modifications and augmented permeability of both the gastrointestinal barrier and the blood-brain barrier (BBB). These alterations facilitate the transit of microbial molecules from the gut to the brain neural, endocrine, and immune pathways, potentially contributing to the etiology of NDs. Numerous investigational strategies, encompassing prebiotic and probiotic interventions, pharmaceutical trials, and dietary adaptations, are actively explored to harness the microbiota for ND treatment. This work endeavors to enhance our comprehension of the intricate mechanisms underpinning ND pathogenesis, offering valuable insights for the development of innovative therapeutic modalities targeting these debilitating disorders.

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2025-04-07

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/content/journals/cn/10.2174/1570159X23666241101093436
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Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases
Curr. Neuropharmacol. 23, 524 (2025); https://doi.org/10.2174/1570159X23666241101093436
/content/journals/cn/10.2174/1570159X23666241101093436
/content/journals/cn/10.2174/1570159X23666241101093436
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  • Article Type:     Review Article
Keyword(s): blood-brain barrier; dietary adaptations; gut microbiota; microbiota-gut-brain axis; Neurodegenerative diseases; therapy

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