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Volume 22, Issue 1
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Bipolar disorders (BD) in youth are associated with a high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related to both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm.

We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models.

Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group. The BD Self-harm group also reported separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD.

Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.

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2024-01-01
2025-01-11

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References

  1. GriffinE. McMahonE. McNicholasF. CorcoranP. PerryI.J. ArensmanE. Increasing rates of self-harm among children, adolescents and young adults: A 10-year national registry study 2007–2016.Soc. Psychiatry Psychiatr. Epidemiol.201853766367110.1007/s00127‑018‑1522‑129721594
     [Google Scholar]
  2. MadgeN. HewittA. HawtonK. WildeE.J. CorcoranP. FeketeS. HeeringenK. LeoD.D. YstgaardM. Deliberate self-harm within an international community sample of young people: comparative findings from the Child & Adolescent Self-harm in Europe (CASE) Study.J. Child Psychol. Psychiatry200849666767710.1111/j.1469‑7610.2008.01879.x18341543
     [Google Scholar]
  3. HawtonK. SaundersK.E.A. O’ConnorR.C. Self-harm and suicide in adolescents.Lancet201237998342373238210.1016/S0140‑6736(12)60322‑522726518
     [Google Scholar]
  4. BrunnerR. KaessM. ParzerP. FischerG. CarliV. HovenC.W. Life-time prevalence and psychosocial correlates of adolescent direct self-injurious behavior: A comparative study of findings in 11 European countries.J. Child. Psychol. Psychiatry. Allied. Discip.2014554337348
     [Google Scholar]
  5. BaldessariniR.J. TondoL. VázquezG.H. UndurragaJ. BolzaniL. YildizA. KhalsaH.M.K. LaiM. LepriB. LolichM. MaffeiP.M. SalvatoreP. FaeddaG.L. VietaE. TohenM. Age at onset versus family history and clinical outcomes in 1,665 international bipolar-I disorder patients.World Psychiatry2012111404610.1016/j.wpsyc.2012.01.00622295008
     [Google Scholar]
  6. MollerC.I. DaveyC.G. BadcockP.B. WrobelA.L. CaoA. MurrihyS. Correlates of suicidality in young people with depressive disorders: A systematic review.2022http://journals.sagepub.com/doi/10.1177/0004867422108649810.1177/00048674221086498
  7. JaniriD. MocciaL. ConteE. PalumboL. ChieffoD.P.R. FreddaG. MenichincheriR.M. BalbiA. KotzalidisG.D. SaniG. JaniriL. Emotional dysregulation, temperament and lifetime suicidal ideation among youths with mood disorders.J. Pers. Med.2021119865 https://www.mdpi.com/2075-4426/11/9/865 10.3390/jpm1109086534575642
     [Google Scholar]
  8. JaniriD. DoucetG.E. PompiliM. SaniG. LunaB. BrentD.A. FrangouS. Risk and protective factors for childhood suicidality: a US population-based study.Lancet Psychiatry20207431732610.1016/S2215‑0366(20)30049‑332171431
     [Google Scholar]
  9. MacPhersonH.A. WeinsteinS.M. WestA.E. Non-suicidal selfinjury in pediatric bipolar disorder: Clinical correlates and impact on psychosocial treatment outcomes.J. Abnorm. Child Psychol.2018464857870 http://link.springer.com/10.1007/s10802-017-0331-4 10.1007/s10802‑017‑0331‑428725956
     [Google Scholar]
  10. Esposito-SmythersC. GoldsteinT. BirmaherB. GoldsteinB. HuntJ. RyanN. AxelsonD. StroberM. GillM.K. HanleyA. KellerM. Clinical and psychosocial correlates of non-suicidal self-injury within a sample of children and adolescents with bipolar disorder.J. Affect. Disord.20101251-38997 http://linkinghub.elsevier.com/retrieve/pii/S016503271000008X 10.1016/j.jad.2009.12.02920089313
     [Google Scholar]
  11. LlamoccaE.N. FristadM.A. BridgeJ.A. BrockG. SteelesmithD.L. AxelsonD.A. FontanellaC.A. Correlates of deliberate self-harm among youth with bipolar disorder.J. Affect. Disord.2022302376384 http://linkinghub.elsevier.com/retrieve/pii/S0165032722000957 10.1016/j.jad.2022.01.08535066010
     [Google Scholar]
  12. CopelandW.E. ShanahanL. HinesleyJ. ChanR.F. AbergK.A. FairbankJ.A. van den OordE.J.C.G. CostelloE.J. Association of childhood trauma exposure with adult psychiatric disorders and functional outcomes.JAMA Netw. Open201817e18449310.1001/jamanetworkopen.2018.449330646356
     [Google Scholar]
  13. Palmier-ClausJ.E. BerryK. BucciS. MansellW. VareseF. Relationship between childhood adversity and bipolar affective disorder: Systematic review and meta-analysis.Br. J. Psychiatry2016209645445910.1192/bjp.bp.115.17965527758835
     [Google Scholar]
  14. HailesH.P. YuR. Europe PMC funders group long-term outcomes of childhood sexual abuse: An umbrella review.Lancet Psychiatry2020610830839
     [Google Scholar]
  15. JaniriD. SaniG. RossiP.D. PirasF. IorioM. BanajN. GiuseppinG. SpinazzolaE. MaggioraM. AmbrosiE. SimonettiA. SpallettaG. Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls.Bipolar Disord.201719535336210.1111/bdi.1251628699182
     [Google Scholar]
  16. JaniriD. De RossiP. KotzalidisG.D. GirardiP. KoukopoulosA.E. ReginaldiD. DottoF. ManfrediG. JollantF. GorwoodP. PompiliM. SaniG. Psychopathological characteristics and adverse childhood events are differentially associated with suicidal ideation and suicidal acts in mood disorders.Eur. Psychiatry201853313610.1016/j.eurpsy.2018.05.00929879623
     [Google Scholar]
  17. WrobelA.L. JayasingheA. RussellS.E. MarxW. AlamedaL. DeanO.M. CottonS.M. BerkM. TurnerA. The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: A systematic review and meta-analysis.J. Affect. Disord.202229635036210.1016/j.jad.2021.09.10334606813
     [Google Scholar]
  18. MarchandW.R. Laurel WirthB.S. Cindy SimonM.S.W. Adverse life events and pediatric bipolar disorder in a community mental health setting.Community Ment. Health J.2005411677510.1007/s10597‑005‑2600‑x15932053
     [Google Scholar]
  19. CazalaF. BauerI.E. MeyerT.D. SpikerD.E. KazimiI.F. ZeniC.P. Zunta-SoaresG.B. SoaresJ.C. Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study.J. Affect. Disord.201924711411910.1016/j.jad.2018.12.00730660020
     [Google Scholar]
  20. RomeroS. BirmaherB. AxelsonD. GoldsteinT. GoldsteinB.I. GillM.K. IosifA.M. StroberM.A. HuntJ. Esposito-SmythersC. RyanN.D. LeonardH. KellerM. Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder.J. Affect. Disord.20091121-314415010.1016/j.jad.2008.04.00518538857
     [Google Scholar]
  21. GoldsteinT.R. BirmaherB. AxelsonD. RyanN.D. StroberM.A. GillM.K. ValeriS. ChiappettaL. LeonardH. HuntJ. BridgeJ.A. BrentD.A. KellerM. History of suicide attempts in pediatric bipolar disorder: Factors associated with increased risk.Bipolar Disord.20057652553510.1111/j.1399‑5618.2005.00263.x16403178
     [Google Scholar]
  22. BaldessariniR.J. BolzaniL. CruzN. JonesP.B. LaiM. LepriB. PerezJ. SalvatoreP. TohenM. TondoL. VietaE. Onset-age of bipolar disorders at six international sites.J. Affect. Disord.20101211-214314610.1016/j.jad.2009.05.03019560827
     [Google Scholar]
  23. BernsteinD.P. SteinJ.A. NewcombM.D. WalkerE. PoggeD. AhluvaliaT. StokesJ. HandelsmanL. MedranoM. DesmondD. ZuleW. Development and validation of a brief screening version of the Childhood Trauma Questionnaire.Child Abuse Negl.200327216919010.1016/S0145‑2134(02)00541‑012615092
     [Google Scholar]
  24. WangM. PengC. ChangH. YuM. RongF. YuY. Interaction between Sirtuin 1 (SIRT1) polymorphisms and childhood maltreatment on aggression risk in Chinese male adolescents.J. Affect. Disord.20223093744
     [Google Scholar]
  25. AngelakisI. GillespieE.L. PanagiotiM. Childhood maltreatment and adult suicidality: A comprehensive systematic review with meta-analysis.Psychol. Med.20194971057107810.1017/S003329171800382330608046
     [Google Scholar]
  26. GladstoneG.L. ParkerG.B. MitchellP.B. MalhiG.S. WilhelmK. AustinM.P. Implications of childhood trauma for depressed women: An analysis of pathways from childhood sexual abuse to deliberate self-harm and revictimization.Am. J. Psychiatry200416181417142510.1176/appi.ajp.161.8.141715285968
     [Google Scholar]
  27. RussellA.E. HeronJ. GunnellD. FordT. HemaniG. JoinsonC. MoranP. ReltonC. SudermanM. MarsB. Pathways between early‐life adversity and adolescent self‐harm: The mediating role of inflammation in the avon longitudinal study of parents and children.J. Child Psychol. Psychiatry201960101094110310.1111/jcpp.1310031486089
     [Google Scholar]
  28. AasM. BellivierF. BettellaF. HenryC. GardS. KahnJ.P. LagerbergT.V. AminoffS.R. MelleI. LeboyerM. JamainS. AndreassenO.A. EtainB. Childhood maltreatment and polygenic risk in bipolar disorders.Bipolar Disord.202022217418110.1111/bdi.1285131628696
     [Google Scholar]
  29. DimickM.K. HirdM.A. SultanA.A. MitchellR.H.B. SinyorM. MacIntoshB.J. GoldsteinB.I. Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.Psychol. Med.202211010.1017/S003329172100541935256032
     [Google Scholar]
  30. TeicherM.H. SamsonJ.A. Annual research review: Enduring neurobiological effects of childhood abuse and neglect.J. Child Psychol. Psychiatry201657324126610.1111/jcpp.1250726831814
     [Google Scholar]
  31. SimonettiA. SaxenaK. KoukopoulosA.E. JaniriD. LijffijtM. SwannA.C. KotzalidisG.D. SaniG. Amygdala structure and function in paediatric bipolar disorder and high-risk youth: A systematic review of magnetic resonance imaging findings.World J. Biol. Psychiatry202223210312610.1080/15622975.2021.193531734165050
     [Google Scholar]
  32. JaniriD. KotzalidisG.D. De ChiaraL. KoukopoulosA.E. AasM. SaniG. The ring of fire.Psychiatr. Clin. North Am.2020431698210.1016/j.psc.2019.10.00732008689
     [Google Scholar]
  33. PehC.X. ShahwanS. FauzianaR. MaheshM.V. SambasivamR. ZhangY. OngS.H. ChongS.A. SubramaniamM. Emotion dysregulation as a mechanism linking child maltreatment exposure and self-harm behaviors in adolescents.Child Abuse Negl.20176738339010.1016/j.chiabu.2017.03.01328371647
     [Google Scholar]
  34. JohnsonJ.G. CohenP. GouldM.S. KasenS. BrownJ. BrookJ.S. Childhood adversities, interpersonal difficulties, and risk for suicide attempts during late adolescence and early adulthood.Arch. Gen. Psychiatry200259874174910.1001/archpsyc.59.8.74112150651
     [Google Scholar]
  35. SteinhoffA. BechtigerL. RibeaudD. EisnerM. ShanahanL. Self-, other-, and dual-harm during adolescence: A prospective-longitudinal study of childhood risk factors and early adult correlates.Psychol. Med.20221910.1017/S003329172200066635297361
     [Google Scholar]
  36. KlosinskiG. Psychological maltreatment in the context of separation and divorce.Child Abuse Negl.199317455756310.1016/0145‑2134(93)90030‑98402258
     [Google Scholar]
  37. CentorrinoF. FogartyK.V. SaniG. SalvatoreP. CimbolliP. BaldessariniR.J. Antipsychotic drug use: McLean Hospital, 2002.Hum. Psychopharmacol.200520535535810.1002/hup.70015957153
     [Google Scholar]
  38. MusengaA. SaracinoM. SaniG. RaggiM. Antipsychotic and antiepileptic drugs in bipolar disorder: The importance of therapeutic drug monitoring.Curr. Med. Chem.200916121463148110.2174/09298670978790960419355900
     [Google Scholar]
  39. Daruy-FilhoL. BrietzkeE. LaferB. Grassi-OliveiraR. Childhood maltreatment and clinical outcomes of bipolar disorder.Acta Psychiatr. Scand.2011124642743410.1111/j.1600‑0447.2011.01756.x21848703
     [Google Scholar]
  40. WoolwayG.E. SmartS.E. LynhamA.J. LloydJ.L. OwenM.J. JonesI.R. Schizophrenia polygenic risk and experiences of childhood adversity: A systematic review and meta-analysis.Schizophr Bull10.1093/schbul/sbac049
     [Google Scholar]
  41. DobaK. SaloppéX. ChoukriF. NandrinoJ.L. Childhood trauma and posttraumatic stress symptoms in adolescents and young adults: The mediating role of mentalizing and emotion regulation strategies.Child Abuse Negl.202213210581510.1016/j.chiabu.2022.10581535914329
     [Google Scholar]
  42. RieneckeR.D. JohnsonC. Le GrangeD. ManwaringJ. MehlerP.S. DuffyA. McClanahanS. BlalockD.V. Adverse childhood experiences among adults with eating disorders: Comparison to a nationally representative sample and identification of trauma profiles.J. Eat. Disord.20221017210.1186/s40337‑022‑00594‑x35596196
     [Google Scholar]
  43. KuzminskaiteE. VinkersC.H. MilaneschiY. GiltayE.J. PenninxB.W.J.H. Childhood trauma and its impact on depressive and anxiety symptomatology in adulthood: A 6-year longitudinal study.J. Affect. Disord.202231232233010.1016/j.jad.2022.06.05735760192
     [Google Scholar]
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Childhood Trauma and Self-harm in Youths with Bipolar Disorders
Curr. Neuropharmacol. 22, 152 (2024); https://doi.org/10.2174/1570159X21666230213155249
/content/journals/cn/10.2174/1570159X21666230213155249
/content/journals/cn/10.2174/1570159X21666230213155249
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  • Article Type:     Research Article
Keyword(s): Bipolar disorders; childhood trauma; childhood trauma questionnaire; pediatric; self-harm; youth

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