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2000
Volume 15, Issue 1
  • ISSN: 1874-4672
  • E-ISSN: 1874-4702

Abstract

Background: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity. Objective: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product. Conclusion: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

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/content/journals/cmp/10.2174/1874467214666210309115105
2022-01-01
2025-05-19
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/content/journals/cmp/10.2174/1874467214666210309115105
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  • Article Type:
    Review Article
Keyword(s): cancer; cytotoxicity; Ginseng; ginsenoside Rh2; mechanism; natural compound
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