CRH Receptors in Human Reproduction

Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system. Objective: Herein, the role of CRH receptors in the female reproductive system is presented. Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition. Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.