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Volume 24, Issue 11
  • ISSN: 1566-5240
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Abstract

Background

Silver nanoparticles (Ag-NPs) have garnered significant attention in recent years due to their therapeutic effects. Curcumin (CUR) has been utilized as a coating agent for synthesizing Ag-NPs, intended to act as a potential drug.

Objective

This study was designed to evaluate the safety and efficacy of curcumin-synthesized silver nanoparticles on rats exposed to chlorpyrifos (CPF) during their pubertal development.

Methods

Forty-two male Wistar rats, 23 days old, were selected and randomly divided into 7 groups (n=6) as follows: positive control, negative control, CPF (5 mg/kg), silver nanoparticles synthesized using curcumin at 40 µg/kg (CUR-Ag-NPs 40), CUR-Ag-NPs 80, CPF+ CUR-Ag-NPs 40, CPF+ CUR-AgNPs 80. All treatments were administered gavage for 30 days. At the end of the study, rats were anesthetized using ketamine (50 mg/kg), and xylazine, (10 mg/kg) and blood was collected from the heart for serum analysis of liver enzymes, urea, and creatinine.

Results

Liver and kidney tissues were isolated for histopathological analysis. No significant differences were observed in serum levels of AST, ALT, and ALP enzymes as well as urea and creatinine levels among the different groups. Light microscopy observation revealed multifocal inflammatory mononuclear cell subsets in liver tissue associated with mild inflammatory mononuclear cell infiltration in the portal region in CPF, CUR-Ag-NPs 40, CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40, and CPF+CUR-Ag-NPs 80 groups. Histological examination of kidney tissue showed degenerative changes in the tubular epithelium, congestion, and mild infiltration of mononuclear inflammatory cells in the renal interstitial tissue in the CPF group, CUR-Ag-NPs 40, CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40 and CPF+CUR-Ag-NPs 80 groups.

Conclusion

This study failed to establish the safety and efficacy of CUR-Ag-NP at 40 and 80 µg/kg in prepubertal rats exposed to CPF. However, further studies should be conducted to thoroughly characterize the efficacy of CUR-Ag-NP in developmental animal models.

© 2024 Bentham Science Publishers
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2023-11-03
2024-11-30

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References

  1. XuL. WangY.Y. HuangJ. ChenC.Y. WangZ.X. XieH. Silver nanoparticles: Synthesis, medical applications and biosafety.Theranostics202010208996903110.7150/thno.45413 32802176
     [Google Scholar]
  2. SimonS. SibuyiN.R.S. FadakaA.O. Biomedical applications of plant extract-synthesized silver nanoparticles.Biomedicines20221011279210.3390/biomedicines10112792 36359308
     [Google Scholar]
  3. MuhamadM. Ab RahimN. Wan OmarW.A. Nik Mohamed KamalN.N.S. Cytotoxicity and genotoxicity of biogenic silver nanoparticles in A549 and BEAS-2B cell lines.Bioinorg. Chem. Appl.20222022854607910.1155/2022/8546079 36193250
     [Google Scholar]
  4. YangY. GuoL. WangZ. Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization.Biomaterials202126412039010.1016/j.biomaterials.2020.120390 32980634
     [Google Scholar]
  5. WahabS. KhanT. AdilM. KhanA. Mechanistic aspects of plant-based silver nanoparticles against multi-drug resistant bacteria.Heliyon202177e0744810.1016/j.heliyon.2021.e07448 34286126
     [Google Scholar]
  6. WenL. LiM. LinX. LiY. SongH. ChenH. AgNPs aggravated hepatic steatosis, inflammation, oxidative stress, and epigenetic changes in mice with NAFLD induced by HFD.Front. Bioeng. Biotechnol.20221091217810.3389/fbioe.2022.912178 35677306
     [Google Scholar]
  7. LuC. LvY. KouG. Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio).Ecotoxicol. Environ. Saf.202224311399310.1016/j.ecoenv.2022.113993 35994909
     [Google Scholar]
  8. YuanY.G. CaiH.Q. WangJ.L. Graphene oxide-silver nanoparticle nanocomposites induce oxidative stress and aberrant methylation in caprine fetal fibroblast cells.Cells202110368210.3390/cells10030682 33808775
     [Google Scholar]
  9. UllahI. KhalilA.T. AliM. Green-synthesized silver nanoparticles induced apoptotic cell death in MCF-7 breast cancer cells by generating reactive oxygen species and activating caspase 3 and 9 enzyme activities.Oxid. Med. Cell. Longev.2020202011410.1155/2020/1215395 33082906
     [Google Scholar]
  10. SinghA. RajA. PadmanabhanA. ShahP. AgrawalN. Combating silver nanoparticle‐mediated toxicity inDROSOPHILA MELANOGASTER with curcumin.J. Appl. Toxicol.20214181188119910.1002/jat.4103 33146454
     [Google Scholar]
  11. MemarziaA. KhazdairM.R. BehrouzS. Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCURCUMA LONGA and curcumin, an updated and comprehensive review.Biofactors202147331135010.1002/biof.1716 33606322
     [Google Scholar]
  12. ForouzanfarF. ForouzanfarA. SathyapalanT. OrafaiH.M. SahebkarA. Curcumin for the management of periodontal diseases: A review.Curr. Pharm. Des.202026344277428410.2174/1381612826666200513112607 32400326
     [Google Scholar]
  13. SuwalN. SubbaR.K. PaudyalP. KhanalD.P. PanthiM. SuwalN. Antimicrobial and antibiofilm potential of Curcuma longa Linn. Rhizome extract against biofilm producing Staphylococcus aureus and Pseudomonas aeruginosa isolates.Cell. Mol. Biol. (Noisy-le-grand)20216711723
     [Google Scholar]
  14. FilardiT. VarìR FerrettiE ZicariA MoranoS SantangeloC. Curcumin: Could this compound be useful in pregnancy and pregnancy-related complications?Nutrients20201210317910.3390/nu12103179 33080891
     [Google Scholar]
  15. KarthikeyanA. SenthilN. MinT. Nanocurcumin: A promising candidate for therapeutic applications.Front. Pharmacol.20201148710.3389/fphar.2020.00487 32425772
     [Google Scholar]
  16. NandiN.K. VyasA. AkhtarM.J. KumarB. The growing concern of chlorpyrifos exposures on human and environmental health.Pestic. Biochem. Physiol.202218510513810.1016/j.pestbp.2022.105138 35772841
     [Google Scholar]
  17. EbaidH. HabilaM. HassanI. Curcumin-containing silver nanoparticles prevent carbon tetrachloride- induced hepatotoxicity in mice.Comb. Chem. High Throughput Screen.202124101609161710.2174/1386207323666201211100830 33308125
     [Google Scholar]
  18. BurdușelA.C. GherasimO. GrumezescuA.M. MogoantăL. FicaiA. AndronescuE. Biomedical applications of silver nanoparticles: An up-to-date overview.Nanomaterials20188968110.3390/nano8090681 30200373
     [Google Scholar]
  19. KumariS.C. PadmaP.N. AnuradhaK. Green silver nanoparticles embedded in cellulosic network for fresh food packaging.J. Pure Appl. Microbiol.20211531236124410.22207/JPAM.15.3.13
     [Google Scholar]
  20. LvY. LiuH. WangZ. Silver nanoparticle-decorated porous ceramic composite for water treatment.J. Membr. Sci.20093311-2505610.1016/j.memsci.2009.01.007
     [Google Scholar]
  21. AbdelazizM.H. El‐DakdokyM.H. AhmedT.A. MohamedA.S. Biological impacts of the green synthesized silver nanoparticles on the pregnant albino rats and their fetuses.Birth Defects Res.2023115444145710.1002/bdr2.2131
     [Google Scholar]
  22. NakkalaJ.R. MataR. RajaK. Khub ChandraV. SadrasS.R. Green synthesized silver nanoparticles: Catalytic dye degradation, in vitro anticancer activity and in vivo toxicity in rats.Mater. Sci. Eng. C20189137238110.1016/j.msec.2018.05.048 30033267
     [Google Scholar]
  23. TarbaliS. Karami MehrianS. KhezriS. Toxicity effects evaluation of green synthesized silver nanoparticles on intraperitoneally exposed male Wistar rats.Toxicol. Mech. Methods202232748850010.1080/15376516.2022.2049412 35253611
     [Google Scholar]
  24. MathiasF.T. RomanoR.M. KizysM.M.L. Daily exposure to silver nanoparticles during prepubertal development decreases adult sperm and reproductive parameters.Nanotoxicology201591647010.3109/17435390.2014.889237 24533579
     [Google Scholar]
  25. de OliveiraI.M. CavallinM.D. CorrêaD.E.C. Proteomic profiles of thyroid gland and gene expression of the hypothalamic-pituitary-thyroid axis are modulated by exposure to AgNPs during prepubertal rat stages.Chem. Res. Toxicol.202033102605262210.1021/acs.chemrestox.0c00250 32972137
     [Google Scholar]
  26. EmaM. OkudaH. GamoM. HondaK. A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals.Reprod. Toxicol.20176714916410.1016/j.reprotox.2017.01.005 28088501
     [Google Scholar]
/content/journals/cmm/10.2174/0115665240259497231020070225
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Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development
Current Molecular Medicine 24, 1437 (2024); https://doi.org/10.2174/0115665240259497231020070225
/content/journals/cmm/10.2174/0115665240259497231020070225
/content/journals/cmm/10.2174/0115665240259497231020070225
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  • Article Type:     Research Article
Keyword(s): chlorpyrifos; CUR-Ag-NP; efficacy; puberty development; rats; safety

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