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Volume 24, Issue 11
  • ISSN: 1566-5240
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Abstract

Background

Silver nanoparticles (Ag-NPs) have garnered significant attention in recent years due to their therapeutic effects. Curcumin (CUR) has been utilized as a coating agent for synthesizing Ag-NPs, intended to act as a potential drug.

Objective

This study was designed to evaluate the safety and efficacy of curcumin-synthesized silver nanoparticles on rats exposed to chlorpyrifos (CPF) during their pubertal development.

Methods

Forty-two male Wistar rats, 23 days old, were selected and randomly divided into 7 groups (n=6) as follows: positive control, negative control, CPF (5 mg/kg), silver nanoparticles synthesized using curcumin at 40 µg/kg (CUR-Ag-NPs 40), CUR-Ag-NPs 80, CPF+ CUR-Ag-NPs 40, CPF+ CUR-AgNPs 80. All treatments were administered gavage for 30 days. At the end of the study, rats were anesthetized using ketamine (50 mg/kg), and xylazine, (10 mg/kg) and blood was collected from the heart for serum analysis of liver enzymes, urea, and creatinine.

Results

Liver and kidney tissues were isolated for histopathological analysis. No significant differences were observed in serum levels of AST, ALT, and ALP enzymes as well as urea and creatinine levels among the different groups. Light microscopy observation revealed multifocal inflammatory mononuclear cell subsets in liver tissue associated with mild inflammatory mononuclear cell infiltration in the portal region in CPF, CUR-Ag-NPs 40, CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40, and CPF+CUR-Ag-NPs 80 groups. Histological examination of kidney tissue showed degenerative changes in the tubular epithelium, congestion, and mild infiltration of mononuclear inflammatory cells in the renal interstitial tissue in the CPF group, CUR-Ag-NPs 40, CUR-Ag-NPs 80, CPF+CUR-Ag-NPs 40 and CPF+CUR-Ag-NPs 80 groups.

Conclusion

This study failed to establish the safety and efficacy of CUR-Ag-NP at 40 and 80 µg/kg in prepubertal rats exposed to CPF. However, further studies should be conducted to thoroughly characterize the efficacy of CUR-Ag-NP in developmental animal models.

© 2024 Bentham Science Publishers
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2023-11-03
2024-10-12

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/content/journals/cmm/10.2174/0115665240259497231020070225
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Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development
Current Molecular Medicine 24, 1437 (2024); https://doi.org/10.2174/0115665240259497231020070225
/content/journals/cmm/10.2174/0115665240259497231020070225
/content/journals/cmm/10.2174/0115665240259497231020070225
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  • Article Type: Research Article
Keyword(s): chlorpyrifos; CUR-Ag-NP; efficacy; puberty development; rats; safety

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