Current Microwave Chemistry - Volume 4, Issue 2, 2017

Background: The introduction of a cyano group has been widely investigated because a cyano group may easily be transformed into both a methylamino moiety and a carboxylic acid moiety. Therefore Michael addition between phenol and acrylonitrile for the introduction of a cyanoethoxy moiety has been reported by several groups, however, the long reaction time (20-40 h) of this reaction was problematic. In Read More

Background: Recent developments in extraction techniques of natural materials for the value added compounds viz., pigments, volatile oil, bioactive compounds include application of ultra sonication, high pressure extraction, pulsed electric field application, microwave-assisted extraction and enzyme assisted extraction. Essential oil & bioactive compounds from spices are gaining lot of importance recently in vie Read More

Background: Potassium phthalimide (PPI), a mild, green and commercially available organocatalyst used in the synthesis of a wide range of important bioactive compounds. 6-amino-1,4- dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives were synthesized via a four component reaction of ethyl acetoacetate, hydrazine hydrate, aryl aldehydes and malononitrile by utilizing various homogenous as well as heteroge Read More

Background: The p-toluenesulfonyl (tosyl) group is one of the most versatile protecting groups for phenols and alcohols, but its removal requires drastic conditions due to their high stability. Methods: In the course of reaction, (Et4N)O2 was generated in situ by the phase transfer reaction of KO2 and Et4NBr in dry DMF was subsequently allowed to react with tosyl esters, under microwave irradiation. Results: Tosyl esters were Read More

Background: The advantages of microwave (MW)-assisted chemistry reactions have led several research groups to apply this technique to the optimization of synthetic processes and the preparation of new compounds. This research focuses on Knoevenagel condensation with additives supported on natural fibers (Fibroin and Kapok) under MW. Methods: Under these experimental conditions, 2-benzylidenemalononitrile w Read More

Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time. Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and e Read More

Background: A convenient synthesis of series of functionalized 5-(substituted phenyl)-3-phenylisoxazole (4a-f) has been carried out by using established procedures. First of all,α,β- unsaturated carbonyl compounds, Chalcones (3) were synthesized by reacting different substituted benzaldehydes (1) with acetophenone (2) based on the mechanism involved in Claisen-Schimidt condensation. Methods: Various Isoxazol Read More

Background: Stress testing as an important segment in the process of getting drug to the market and are intended to reveal stability issues. Methods: In stress testing, it is mentioned to perform the task (hydrolytic or thermolytic degradation) at elevated temperature as and when required. Elevation in temperature by means of microwave irradiation has picked up lot of consideration owing to the in-core heating of Read More

Background: Microwave couples directly with the molecules that are present in the reaction mixture, leading to a rapid, efficient, and instantaneous heating process. For a specific reaction system, the level of this internal heating is depended on the microwave power. Methods: The acid-catalyzed esterification of benzoic acid with butanol was selected as a model reaction to study the influence of the microwave power on the reacti Read More

Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for substituted benzamides has been developed by using salts of carboxylic acids. Methods: In the synthetic method, the targeted substituted benzamides were synthesized with the help of microwave by reacting salts of carboxylic acid and benzamides in the presence of copper and dimethyl formamide. Results: All substituted benzamides were ob Read More

Background: Aminolysis of lactones is an important reaction for the synthesis of hydroxy amides. This reaction generally requires rather harsh conditions, such as high pressure and temperature or strong alkali metal catalysts. Microwave-assisted reactions have provided a great impetus to organic synthesis, especially for accelerating the reactions. The combination of microwave heating and solventfree conditions is a partic Read More

Background: We describe herein a convenient one-pot, microwave-assisted methodology for the synthesis of dihydrospiro[indeno[1,2-b]quinoline-10,3'-indole]-2',4',11(1'H,5H,5'H)-trione derivatives from enaminones, isatins and indane-1,3-dione under catalyst-free condition. Method: The advantages of this microwave-assisted protocol are simplicity, rapidity, high yielding and environmentally benign procedure. Result: In a Read More