Current Microwave Chemistry - Volume 3, Issue 3, 2016

Background: Microwave-assisted organic synthesis has rapidly evolved in the last decade as a well-organized utensil for synthetic chemists. The pyrimidine scaffold still residues as one of the most valuable class of compounds for the synthesis of clinically useful drugs. Molecular docking is frequently used to forecast the binding orientation. The probability of binding of protein to pyrimidine analogues is fascinating and Docki Read More

Background: Microwave-assisted organic synthesis has been a powerful and expedient tool for quick organic synthesis which has vital advantages such as simplicity in process, cumulative rate of reaction, high reaction yields, and less amount of side product etc. Multicomponent reactions have developed chemical transformations for powerful bond-forming in organic, combinatorial and medicinal chemistry. The spirooxindole sy Read More

Background: Small ring nitrogen heterocycles like four membered cyclic carbamates play an important role in medicinal chemistry. The aim of the paper is to facilitate the readers with the green synthesis of carbamates. As the previous reported procedure suffer from one or more demerits such as longer reaction times, obsolete work up procedure, poor yields of the products, and the use of toxic and inflammable solvents. T Read More

Background: Organic reactions accelerated by microwave irradiation is an area of great interest in recent times. Several organic reactions are usually slow under normal or thermal conditions, however, use of microwave irradiation reduces the reaction time significantly. Multi component reactions (MCRs) are of interest due to nature of complex products formed in a one pot reaction. Methods: The reaction (MCR) is accele Read More

Background: In recent time, microwave-assisted procedures are becoming popular ecofriendly approaches in the Green Chemistry. In chemical processing, microwave irradiation is evolving as an efficient tool and has been utilized in various fields including polymer chemistry. Microwave irradiation extends its use in the carboxymethylation of polysaccharides like starch, hemicellusose and chitosan. However, to date, no st Read More

Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach. Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the s Read More

Background: Organophosphates form the basis of many well-known insecticides, herbicides, drugs and nerve agents. Since they belong to the most pervasive synthetic chemicals, a highly efficient method for their degradation has been searched for. Methods: Recently, an efficient microwave-assisted hydrolysis of phosphonate diesters to the corresponding phosphonic acids has been developed. This novel method, employing i Read More

Background: Bemzo and naphthopyranes are biologically relevant heterocycles that demonstrate a wide variety of biological activity. 2-amino-4H-chromenes is among the most compounds that exist in drugs. It is well documented that for chiral drugs one enantiomer possesses biological activity while it’s enantiomer is either inactive or less active. Catalytic asymmetric synthesis of such scaffold is very rare utilizing expensi Read More

Background: Although several methods are reported for the C-S bond formation, the microwave assisted method reported in this work is simple and proceeds with high yields in short time. Methods: In the synthetic method, the targeted aryl sulfides were synthesized with the help of microwave by reacting halobenzenes, substituted thiophenols and potassium carbonate in the presence of dimethyl sulfoxide and water. Read More

Background: Trisubstituted alkenes are synthetically very important and recognised as versatile substrates for Diels-Alder reactions, Michael addition reactions and Morita-Baylis-Hilman reactions. Among the available procedures, Knoevenagel condensation is considered the most efficient method of synthesizing these alkenes. Numerous reaction conditions and catalysts have been reported till date. However, most of these Read More

Background: The synthesis of indoles, which are often derived from 1-acetyl-1H-indol-3-yl acetates, is of considerable synthetic interest, for example due to their medicinal properties, and their applications within microbiology. Whilst several chemical routes are available for accessing indoles, many are lengthy, and their scope for accessing a range of derivatives has not always been demonstrated. Herein, an optimise Read More

Background: Substituted 2-nitroanilines are synthetic intermediates used in the synthesis of important bioactive compounds. Nucleophilic aromatic substitution reactions with activated substrates, such as substituted 5-chloro-2-nitroanilines, usually involve the use of a solvent, high pressure conditions and prolonged reaction times. We describe a simple and straightforward protocol to prepare 5-substituted 2-nitroanilines that Read More