Current Molecular Imaging (Discontinued) - Volume 3, Issue 1, 2014

Background: Limited data are available in the literature comparing brain SPECT, PET and volumetric MRI in the same cohort of patients with Alzheimer’s disease. Objectives: The main goal was to show a correlation between two different functional imaging substrates, as determined by FDG-PET and SPECT, with structural MRI findings as defined by voxel-based volumetric measurements (VBM), in the same cohort of pati Read More

Purpose: To investigate the association between changes on [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and clinical deterioration in patients with moderate Alzheimer’s disease (AD), findings of FDG-PET in the first and follow-up stages were compared using stereotactic extraction estimation (SEE) and three-dimensional stereotactic surface projection (3D-SSP). Methods and patients: Thirty co Read More

Both neuropsychiatric disorders and malignancies of central nervous system (CNS) represent a significant health burden and life-threatening diseases worldwide. Radiotracer-based neuroimaging is an attractive tool that permits the in vivo detection and characterization of metabolic and molecular processes which are fundamental elements for brain function, and improves the theranostics of brain diseases and disorders. Read More

Vascular thrombosis is a crucial event and still cause of significant morbidity and mortality worldwide. Deep vein thrombosis with subsequent pulmonary embolism constitutes a frequent clinical event, while reliable detection, especially of small or old thrombi, still remains clinically challenging. Occlusion or thromboembolism in an arterial vessel may result in myocardial infarction or stroke, and early detection would Read More

The infection of a vascular prosthesis (VGI) is the most serious complication in prosthetic vascular reconstructive surgery, burdened by a high rate of mortality and morbidity. The treatment of a VGI, in most cases, consists of its surgical removal, and therefore an accurate diagnosis of the infection, is of paramount importance in clinical practice since false-positive results may lead to unnecessary major surgery whereas fal Read More

Purpose: Cell surface antigens as biomarkers suggest high potential for early diagnosis in cancers. The scope of this study is to synthesize Gd3+ based silica nanoparticles that conjugate on monoclonal antibody C595 by a facile method in order to detect human prostate cancer cells. Method: In this study, monoclonal antibody C595, anti-MUC-1, was conjugated on Gd3+-based mesoporous silica nanospheres (MSN-Gd3+-C595) Read More

Apoptosis or genetically programmed cell death is a universal phenomenon involving many pathophysiological conditions. Externalization of phosphatidylserine from the inner leaflet to the outer leaflet of the cell membrane is an early event in the apoptotic cascade occurring before membrane blebbing and DNA fragmentation. Annexin A5, a 36 kDa endogenous protein, specifically binds to phosphatidylserine with a n Read More

Burn wounds become colonized with bacteria during the course of recovery. In addition, there are some burn patients whose wounds do not heal for months. In the present study, we attempted to determine: 1. If seeding of a burn wound with Staphylococcus aureus would affect wound healing: and 2. If knocking out IL-6 and TNF, two cytokines commonly associated with burn injury, would alter burn wound healing. Using Read More