Current Medicinal Chemistry - Anti-Infective Agents - Current Issue

Eradication of the pathogen has historically served as a key endpoint in clinical trials of anti-infective therapy. Studies of anti-tuberculous therapy have established the general principle that the rate of clearance of M. tuberculosis may serve as a surrogate marker for the adequacy of its eradication. The best studied of these markers is sputum culture conversion after 2 months of chemotherapy. Closely related measures Read More

At least as long ago as the ancient Egyptians, sulfur-bearing natural products have been used for their potent medicinal properties. Although extracts from leeks were the earliest sulfur-containing substances to be employed for treatment of microbial and parasitic infections, a wide variety of natural and synthetically derived organosulfur compounds have been found to possess important antibiotic properties. There now exi Read More

CycloSal-BVDUMP triesters 32-34 5-[(E)-2-bromovinyl]-2'-deoxyuridine (BVDU 2) have been studied with regard to their potential anti-EBV activity. In addition to the 3'-unmodified cycloSal-BVDUMP triesters 32a-f, the 3'- hydroxyl function has been esterified with different aliphatic carboxylic acids (33a-g) and α-amino acids having natural and non-natural Cα-configuration (34a-m). In addition to the synthesis of these compounds, di Read More

In this review we have tried to present a complete and integrated picture of the old and new ways to discover antibacterial agents. The development of new antibacterial agents can be made from derivatives of known antibacterial agents or by identification of novel agents active against previously unexploited targets. The genetic and biochemical basis of resistance to most classes of antibacterial agents is now kn Read More

Trypanothione reductase is an enzyme that is unique to organisms belonging to the family Trypanosomatidae. Certain trypanosomatids, including trypanosomes and leishmania, are parasitic protozoa that are responsible for several devastating diseases. Trypanothione reductase plays a pivotal role in maintaining the redox balance of trypanosomatids, thus the development of inhibitors of trypanothione reductase may lead to th Read More