Current Metabolomics - Volume 6, Issue 2, 2018

Background: Vibrational spectroscopy has shown the capacity to provide rapid, accurate and relevant information on microorganism's classification and identification. In fact Fourier Transform Infrared Spectroscopy is a sensitive and effective methodology in food analysis, clinical diagnosis and environmental evaluation, with successful identification at genus and species level. Focus: The interest in this technique lies not only in t Read More

Background: Domestic chickens are a valuable yet underutilized set of model organisms for studies relevant to human obesity and adipose metabolism. Chickens and humans share similarities in adipose tissue lipid metabolism, and the in ovo development of the chick enables studies of adipose development that are difficult to perform in other organisms. Transcriptomic and metabolomic studies have begun to characteri Read More

Globally, cancer is one of the leading causes of death, so the development of strategies for an early diagnosis of cancer is of great importance. Biochemical alterations precede morphological changes in cells and tissues, so studying cancer metabolome seems like a reasonable approach for early diagnosis, prognosis and to follow treatment progression. Fourier-Transform Infrared (FTIR) spectroscopy is a valuable tool for stud Read More

Background: Despite cisplatin's effectiveness against ovarian cancer, these cancer cells have shown the ability to resist chemotherapy – a resistance that represents a major obstacle to current therapeutic strategies. Objective: The objective of the study was to determine whether or not cellular resistance could be linked to changes in metabolites. Methods: Liquid Chromatography-mass Spectrometry (LC-MS) hydrophi Read More

Background: Non-digestible carbohydrates are degraded by bacterial fermentation in the large intestine to yield Short-Chain Fatty Acids (SCFAs), such as acetate, propionate and butyrate. SCFAs are known to induce beneficial physiological and metabolic effects in the gut and the host. The pathogenesis of Irritable Bowel Disease (IBD) involves alterations or dysbiosis of the normal intestinal bacterial flora with reductions in b Read More

Background: Lipidomics profiling of urinary exosomes of patients with diabetes mellitus and diabetic nephropathy was performed. Urinary exosomes are a rich source of lipid molecules, which can be used to identify the important signaling lipid molecules. Objective: The lipids are key molecules involved in various signaling pathways of the pathophysiology of diabetes mellitus. To explore the therapeutic potential of thes Read More

Background: Cultivated wheat exists in two ploidies: allotetraploid pasta wheat and allohexaploid bread wheat. Ploidy is known to modify plant metabolism, yet studies comparing metabolomic profiles of allotetraploid and allohexaploid wheat are scarce. Objective: To characterize the ploidy and metabolomic profiles of selected Afghan wheat landraces collected in the 1960's and preserved in Japan and elite wheat cultivars. M Read More

Background: Metabolomics is a relatively new and dominant branch of bioinformatics. Metabolite expression level controls the phenotypic characteristics of any organism. Recently, breast cancer is the leading type of cancer in women across the world, accounting for 25% of all cases. In 2012, it was seen that due to breast cancer, there were 1.68 million cases and 522,000 deaths. Therefore, for drug discovery as well Read More