Current Hypertension Reviews - Volume 16, Issue 3, 2020

Reactive Oxygen Species (ROS) are reactive derivatives of oxygen metabolism. The ROS generation can be mediated by distinctive enzymatic systems including NADPH oxidases. The components of this enzyme are expressed in endothelial and vascular smooth muscle cells, adventitial fibroblasts, and infiltrating monocytes/macrophages. Oxidative stress is a molecular dysregulation in ROS generation/elimination, which Read More

Background: Disruption of redox signaling is a common pathophysiological mechanism observed in several diseases. In hypertension, oxidative stress, resulted either from enhances in Reactive Oxygen Species (ROS) production or decreases in antioxidant defenses, is associated with increase in blood pressure, endothelial dysfunction and vascular remodeling. Although the role of oxidative stress in the development of Read More

Oxidative stress is implicated in the etiology of many ethanol-induced pathologies. Oxidative stress has been shown to contribute to the development of endothelial dysfunction and cardiovascular disease, such as hypertension. This review details mechanisms of vascular function, the role of oxidative stress in vascular biology and how ethanol consumption may alter endothelial and smooth muscle cell function as well a Read More

Most of the systemic blood vessels are surrounded by the perivascular adipose tissue (PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. PVAT-derived adipocytes gener Read More

The use of heavy metals is closely linked to the history of mankind. They have been used as important materials in a wide variety of human activities such as manufacturing utensils and tools. Such extended use has significantly increased professional and environmental exposure to mercury, lead and cadmium. These metals are known to produce hypertension in humans and animals and, among other effects, they c Read More

This article traces the history of the development of artificial intelligence as a science that constantly responds to current problems that arise in medical practice. Attention is drawn to the fact that almost all modern neural systems of medical diagnostics are static. This means that they do not have a time axis, and therefore, can only make diagnoses of diseases at the current time. As a result, doctors have to make prescrip Read More

Background: Preeclampsia is multi-systemic hypertensive pregnancy disorder accompanied by proteinuria. Objectives: To determine the frequency of different presentations of preeclampsia in tertiary care hospital and find out its risk factors. Materials and Methods: The present study was hospital-based cross-sectional study and conducted from 1st August 2015 to 31st July 2016 in Gynaecology and Obstetrics Department, Read More

Background: Pre-eclampsia is a hypertensive pregnancy disorder accompanied by proteinuria. Serum Lactate Dehydrogenase (LDH) is a biochemical marker that reflects the severity and progression of pre-eclampsia. Methods: A cross-sectional study was conducted at the Liaquat University of Medical and Health Sciences (LUMHS). One hundred pre-eclamptic women were enrolled and categorized into mild (n=30) Read More

Background: Arterial hypertension is among the leading causes of mortality worldwide. The primary non-pharmacological management of arterial hypertension is isometric grip training, which has shown better results than pharmacological methods; however, it has not been thoroughly studied in large muscle groups. Objective: This study compared the pressor response of isometric exercise training at different intensities, in lar Read More

Background: In the trial known as COPE (Combination Therapy of Hypertension to Prevent Cardiovascular Events), three benidipine (a Calcium Channel Blocker; CCB) regimens were compared. Hypertensive Japanese outpatients aged 40–85 years (n=3,293) who did not achieve the target blood pressure of <140/90 mmHg with benidipine 4 mg/day were treated with the diuretic thiazide (n=1,094) or a β-blocker (n=1,089) o Read More