Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current HIV Research
  4. Volume 22, Issue 6
  5. Article
Volume 22, Issue 6
  • ISSN: 1570-162X
  • E-ISSN: 1873-4251

Abstract

People Living with HIV (PLHIV) experience accelerated aging, yet strategies for healthy aging in this group are not well studied. Although survival rates have improved, non-infectious comorbidities, like cardiovascular diseases, diabetes, and cancers, are increasing and tend to appear earlier and more severely in PLHIV frailty, defined as increased vulnerability to stressors, which is a growing concern among aging PLHIV, driven by factors, like chronic inflammation, antiretroviral therapy toxicity, and traditional risk factors. Key areas of focus include inactivity, sarcopenia, vitamin D deficiency, and polypharmacy. Addressing these factors is crucial to preventing functional decline and improving the quality of life of PLHIV, though more research is necessary. The aim of this article was to identify and conduct a narrative review of these factors in a pragmatic way in order to facilitate the clinicians.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/chr/10.2174/011570162X335757241111062709
2024-12-01
2025-04-06

  • From This Site

    /content/journals/chr/10.2174/011570162X335757241111062709
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. JiménezZ. Sánchez-CondeM. BrañasF. HIV infection as a cause of accelerated aging and frailty.Rev. Esp. Geriatr. Gerontol.201853210511010.1016/j.regg.2017.04.00728601217
     [Google Scholar]
  2. AlthoffK.N. JacobsonL.P. CranstonR.D. DetelsR. PhairJ.P. LiX. MargolickJ.B. Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men.J Gerontol: Series A201469A218919810.1093/gerona/glt14824127428
     [Google Scholar]
  3. GuaraldiG. OrlandoG. ZonaS. MenozziM. CarliF. GarlassiE. BertiA. RossiE. RoveratoA. PalellaF. Premature age-related comorbidities among HIV-infected persons compared with the general population.Clin. Infect. Dis.201153111120112610.1093/cid/cir62721998278
     [Google Scholar]
  4. GuaraldiG. MalagoliA. CalcagnoA. MussiC. CelesiaB.M. CarliF. PiconiS. De SocioG.V. CattelanA.M. OrofinoG. RivaA. FocàE. NozzaS. Di PerriG. The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: A cross sectional study of people aged 65 – 74 years and more than 75 years.BMC Geriatr.20181819910.1186/s12877‑018‑0789‑029678160
     [Google Scholar]
  5. SchoutenJ. WitF.W. StolteI.G. KootstraN.A. van der ValkM. GeerlingsS.E. PrinsM. ReissP. ReissP. WitF.W.N.M. van der ValkM. SchoutenJ. KooijK.W. van ZoestR.A. ElsengaB.C. PrinsM. StolteI.G. MartensM. MollS. BerkelJ. MollerL. VisserG.R. WellingC. ZaheriS. HillebregtM.M.J. GrasL.A.J. RuijsY.M.C. BenschopD.P. ReissP. KootstraN.A. Harskamp-HolwerdaA.M. MaurerI. Mangas RuizM.M. GirigorieA.F. van LeeuwenE. JanssenF.R. HeidenrijkM. SchrijverJ.H.N. ZikkenheinerW. WezelM. Jansen-KokC.S.M. GeerlingsS.E. GodfriedM.H. GoorhuisA. van der MeerJ.T.M. NellenF.J.B. van der PollT. PrinsJ.M. ReissP. van der ValkM. WiersingaW.J. WitF.W.N.M. van EdenJ. HenderiksA. van HesA.M.H. MutschelknaussM. NobelH.E. PijnappelF.J.J. WestermanA.M. de JongJ. PostemaP.G. BisschopP.H.L.T. SerlieM.J.M. LipsP. DekkerE. de RooijS.E.J.A. WillemsenJ.M.R. VogtL. SchoutenJ. PortegiesP. SchmandB.A. GeurtsenG.J. ter StegeJ.A. Klein TwennaarM. van Eck-SmitB.L.F. de JongM. RichelD.J. VerbraakF.D. DemirkayaN. VisserI. RuheH.G. NieuwkerkP.T. van SteenwijkR.P. DijkersE. MajoieC.B.L.M. CaanM.W.A. SuT. van LunsenH.W. NievaardM.A.F. van den BornB.J.H. StroesE.S.G. MulderW.M.C. AGEhIV Cohort Study Group Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study.Clin. Infect. Dis.201459121787179710.1093/cid/ciu70125182245
     [Google Scholar]
  6. Abizanda-SolerP. Rodriguez-MañasL. Geriatric Medicine Treatise: Fundamentals of Health Care for the Elderly.Elsevier2nd ed2020
     [Google Scholar]
  7. DeeksS.G. HIV infection, inflammation, immunosenescence, and aging.Annu. Rev. Med.201162114115510.1146/annurev‑med‑042909‑09375621090961
     [Google Scholar]
  8. FülöpT. HerbeinG. CossarizzaA. WitkowskiJ.M. FrostE. DupuisG. PawelecG. LarbiA. Cellular senescence, immunosenescence and HIV.Interdiscip. Top. Gerontol. Geriatr.201742284610.1159/00044854227875822
     [Google Scholar]
  9. LagathuC CossarizzaA BéréziatV NasiM CapeauJ PintiM Basic science and pathogenesis of ageing with HIV: Potential mechanisms and biomarkers.AIDS201731Suppl 2S105S11910.1097/QAD.0000000000001441
     [Google Scholar]
  10. NogueiraÁ. ÁlvarezG. RussoF. San-JoséB. Sánchez-TomeroJ.A. BarrilG. Is SPPB useful as a screening method for functional capacity in patients with advanced chronic kidney disease?Nefrología (Engl. Ed.)201939548949610.1016/j.nefroe.2019.01.01030971342
     [Google Scholar]
  11. CraneH.M. MillerM.E. PierceJ. WilligA.L. CaseM.L. WilkinA.M. BrownS. AsirotM.G. FredericksenR.J. SaagM.S. LandayA.L. HighK.P. Physical functioning among patients aging with human immunodeficiency virus (HIV) versus HIV uninfected: Feasibility of using the short physical performance battery in clinical care of people living with HIV aged 50 or older.Open Forum Infect. Dis.201963ofz03810.1093/ofid/ofz03830882010
     [Google Scholar]
  12. ÁlvarezS. BrañasF. Sánchez-CondeM. MorenoS. López-Bernaldo de QuirósJ.C. Muñoz-FernándezM.Á. Frailty, markers of immune activation and oxidative stress in HIV infected elderly.PLoS One2020153e023033910.1371/journal.pone.023033932187205
     [Google Scholar]
  13. KullerL.H. TracyR. BellosoW. WitS.D. DrummondF. LaneH.C. LedergerberB. LundgrenJ. NeuhausJ. NixonD. PatonN.I. NeatonJ.D. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.PLoS Med.2008510e20310.1371/journal.pmed.005020318942885
     [Google Scholar]
  14. MilicJ. RusswurmM. Cerezales CalvinoA. BrañasF. Sánchez- CondeM. GuaraldiG. European cohorts of older HIV adults: POPPY, AGEhIV, GEPPO, COBRA and FUNCFRAIL.Eur. Geriatr. Med.201910224725710.1007/s41999‑019‑00170‑834652761
     [Google Scholar]
  15. BlochM. JohnM. SmithD. RasmussenT.A. WrightE. Managing HIV-associated inflammation and ageing in the era of modern ART.HIV Med.202021S3Suppl. 321610.1111/hiv.1295233022087
     [Google Scholar]
  16. Casas-HerreroA. Anton-RodrigoI. Zambom-FerraresiF. Sáez de AsteasuM.L. Martinez-VelillaN. Elexpuru-EstombaJ. Marin-EpeldeI. Ramon-EspinozaF. Petidier-TorregrosaR. Sanchez-SanchezJ.L. IbañezB. IzquierdoM. Effect of a multicomponent exercise programme (VIVIFRAIL) on functional capacity in frail community elders with cognitive decline: Study protocol for a randomized multicentre control trial.Trials201920136210.1186/s13063‑019‑3426‑031208471
     [Google Scholar]
  17. Martínez-VelillaN. Casas-HerreroA. Zambom-FerraresiF. Sáez de AsteasuM.L. LuciaA. GalbeteA. García-BaztánA. Alonso-RenedoJ. González-GlaríaB. Gonzalo-LázaroM. Apezteguía IráizozI. Gutiérrez-ValenciaM. Rodríguez-MañasL. IzquierdoM. Effect of exercise intervention on functional decline in very elderly patients during acute hospitalization.JAMA Intern. Med.20191791283610.1001/jamainternmed.2018.486930419096
     [Google Scholar]
  18. IzquierdoM. Multicomponent physical exercise program: Vivifrail.Nutr Hosp201936Spec No25056
     [Google Scholar]
  19. DianatinasabM. GhahriS. DianatinasabA. AmanatS. FararoueiM. Effects of exercise on the immune function, quality of life, and mental health in HIV/AIDS individuals.Adv Exp Med Biol20201228411421
     [Google Scholar]
  20. FriedL.P. TangenC.M. WalstonJ. NewmanA.B. HirschC. GottdienerJ. SeemanT. TracyR. KopW.J. BurkeG. McBurnieM.A. Frailty in older adults: Evidence for a phenotype.J. Gerontol. A Biol. Sci. Med. Sci.2001563M146M15710.1093/gerona/56.3.M14611253156
     [Google Scholar]
  21. van KanG.A. RollandY.M. MorleyJ.E. VellasB. Frailty: Toward a clinical definition.J. Am. Med. Dir. Assoc.200892717210.1016/j.jamda.2007.11.00518261696
     [Google Scholar]
  22. BrañasF. GalindoM.J. TorralbaM. AntelaA. VergasJ. RamírezM. RyanP. DrondaF. BuscaC. MachucaI. BustinduyM.J. CabelloA. Sánchez-CondeM. Different profiles among older adults with HIV according to their chronological age and the year of HIV diagnosis: The FUNCFRAIL cohort study (GeSIDA 9817).PLoS One2022173e026619110.1371/journal.pone.026619135353855
     [Google Scholar]
  23. Cruz-JentoftA.J. BahatG. BauerJ. BoirieY. BruyèreO. CederholmT. CooperC. LandiF. RollandY. SayerA.A. SchneiderS.M. SieberC.C. TopinkovaE. VandewoudeM. VisserM. ZamboniM. BautmansI. BaeyensJ-P. CesariM. CherubiniA. KanisJ. MaggioM. MartinF. MichelJ-P. PitkalaK. ReginsterJ-Y. RizzoliR. Sánchez-RodríguezD. ScholsJ. Sarcopenia: Revised European consensus on definition and diagnosis.Age Ageing2019481163110.1093/ageing/afy16930312372
     [Google Scholar]
  24. MijnarendsD.M. KosterA. ScholsJ.M.G.A. MeijersJ.M.M. HalfensR.J.G. GudnasonV. EiriksdottirG. SiggeirsdottirK. SigurdssonS. JónssonP.V. MeirellesO. HarrisT. Physical activity and incidence of sarcopenia: The population-based AGES—Reykjavik Study.Age Ageing201645561462010.1093/ageing/afw09027189729
     [Google Scholar]
  25. CederholmT. Overlaps between frailty and sarcopenia definitions.Nestle Nutr. Inst. Workshop Ser.201583657010.1159/00038206326484770
     [Google Scholar]
  26. Dos-Santos-QuaresmaM.V.L. Lima-RibeiroS.M. Sarcopenia in persons living with HIV under antiretroviral therapy: Literature review.AIDS Rev.202224111534082442
     [Google Scholar]
  27. HawkinsKL BrownTT MargolickJB ErlandsonKM Geriatric syndromes: New frontiers in HIV and sarcopenia.AIDS201731Suppl 2S137S146
     [Google Scholar]
  28. BrañasF. Sánchez-CondeM. CarliF. MenozziM. RaimondiA. MilicJ. FranconiJ. CuomoG. MussiniC. MorenoS. GuaraldiG. Sex differences in people aging with HIV.J. Acquir. Immune Defic. Syndr.202083328429110.1097/QAI.000000000000225932032279
     [Google Scholar]
  29. ThuppalS.V. JunS. CowanA. BaileyR.L. The nutritional status of HIV-infected US adults.Curr. Dev. Nutr.2017110e00163610.3945/cdn.117.00163629955683
     [Google Scholar]
  30. WilliamsS.B. BartschG. MuurahainenN. CollinsG. RaghavanS.S. WheelerD. Protein intake is positively associated with body cell mass in weight-stable HIV-infected men.J. Nutr.200313341143114610.1093/jn/133.4.114312672933
     [Google Scholar]
  31. RuizM. KamermanL.A. Nutritional screening tools for HIV-infected patients: Implications for elderly patients.J. Int. Assoc. Physicians AIDS Care (Chic.)20109636236710.1177/154510971038450421138832
     [Google Scholar]
  32. López JiménezE. Neira ÁlvarezM. Ramírez MartínR. Alonso BouzónC. Amor AndrésM.S. Bermejo BoixareuC. BrañasF. Menéndez ColinoR. Arias MuñanaE. Checa LópezM. Grau JiménezC. Pérez RodríguezP. Alcantud IbáñezM. Vasquez BrolenB. OlivaJ. Peña LongobardoL.M. Alcantud CórcolesR. Cortés ZamoraE.B. Gómez JiménezE. Romero RizosL. Avendaño CéspedesA. Hernández SocorroC.R. AbizandaP. “Sarcopenia measured by ultrasound in hospitalized older adults” (ECOSARC): Multi-centre, prospective observational study protocol.BMC Geriatr.202323116310.1186/s12877‑023‑03891‑536949412
     [Google Scholar]
  33. Marcos-PérezD. Sánchez-FloresM. ProiettiS. BonassiS. CostaS. TeixeiraJ.P. Fernández-TajesJ. PásaroE. ValdiglesiasV. LaffonB. Low vitamin D levels and frailty status in older adults: A systematic review and meta-analysis.Nutrients2020128228610.3390/nu1208228632751730
     [Google Scholar]
  34. BenguellaL. ArbaultA. FillionA. BlotM. PirothC. DenimalD. DuvillardL. OrnettiP. ChavanetP. MaillefertJ.F. PirothL. Vitamin D supplementation, bone turnover, and inflammation in HIV-infected patients.Med. Mal. Infect.201848744945610.1016/j.medmal.2018.02.01129661598
     [Google Scholar]
  35. FernerR.E. AronsonJ.K. Communicating information about drug safety.BMJ2006333755914314510.1136/bmj.333.7559.14316840480
     [Google Scholar]
  36. OkanovicN. TanE.C. DooleyM.J. KirkpatrickC.M. BellJ.S. Prevalence and factors associated with polypharmacy in long-term care facilities: A systematic review.J. Am. Med. Dir. Assoc.201516535.e1535.e2
     [Google Scholar]
  37. Gimeno-GraciaM. Prevalence of polypharmacy and pharmacotherapy complexity in elderly people living with HIV in Spain. Point studyFarm Hosp2020444127134
     [Google Scholar]
  38. Delgado SilveiraE. Spanish version of the STOPP/START 3 criteria: Advances in the detection of inappropriate prescribing medication in the older people.Rev Esp Geriatr Gerontol2023585101407
     [Google Scholar]
  39. BlancoJ.R. MorilloR. Pharmacological deprescription of non-antiretroviral therapy in patients with hiv infection2018Available from: https://gesida-seimc.org/wpcontent/uploads/2019/03/15_DESPRESCRIPCION_FARMACOLOGICA_TERAPIA_NO_ANTIRRETROVIRAL_EN_PACIENTES_CON_INFECCION_POR_VIH.pdf
  40. Gutiérrez-ValenciaM. IzquierdoM. CesariM. Casas-HerreroÁ. InzitariM. Martínez-VelillaN. The relationship between frailty and polypharmacy in older people: A systematic review.Br. J. Clin. Pharmacol.20188471432144410.1111/bcp.1359029575094
     [Google Scholar]
/content/journals/chr/10.2174/011570162X335757241111062709
Loading
A Perspective on Frailty and its Predisposing Factors among People Living with HIV
Current HIV Research 22, 349 (2024); https://doi.org/10.2174/011570162X335757241111062709
/content/journals/chr/10.2174/011570162X335757241111062709
/content/journals/chr/10.2174/011570162X335757241111062709
Loading

Data & Media loading...


  • Article Type:     Editorial
Keyword(s): cardiovascular diseases; Frailty; HIV; polypharmacy; sarcopenia; vitamin D

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test