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Volume 24, Issue 3
  • ISSN: 1871-529X
  • E-ISSN: 2212-4063

Abstract

Background

Hypertension is a major risk factor for cardiovascular diseases. (PB) is used for the treatment of hypertension, painful sprains, skin diseases, tuberculosis, acute bronchitis, anti-inflammatory conditions, hepatitis, and diabetes. Its antihypertensive potential has been investigated and documented. This study investigated the antihypertensive mechanism of aqueous extract of PB leaf (APB) on L-NAME-induced hypertension.

Methods

Thirty male wistar rats (150-170 g) were grouped into five (n=5). Group 1 received 10 mL/kg of distilled water (control), while groups 2-5 were administered 60 mg/k of L-NAME (L-NAME60) orally for eight weeks to induce hypertension. After eight weeks, groups 2-5 received L-NAME60+distilled water (HNT), distilled water (HRE), L-NAME60+APB (200 mg/kg, [HAPB]), and L-NAME60+ramipril (10 mg/kg, [HRA]), respectively, for five weeks. The BP was measured by the tail-cuff method. The blood sample was obtained under anesthesia, and tissue samples were obtained after euthanasia. Serum renin, ACE, angiotensin-II, endothelin-1, and cyclic guanosine monophosphate (cGMP) levels were measured using ELISA techniques. Malondialdehyde, superoxide dismutase (SOD), and reduced glutathione (GSH) levels were measured by spectrophotometry. Data were analyzed using ANOVA at α0.05.

Results

The BP significantly decreased in HAPB compared to HNT. Renin, ACE, and angiotensin-II levels significantly decreased while cGMP levels increased in the HAPB group compared to HNT. Malondialdehyde levels significantly decreased, and SOD and GSH levels increased compared to HNT.

Conclusion

aqueous leaf extract reduced blood pressure in hypertensive rats by modulating the cGMP signalling pathway and the renin-angiotensin system.

© 2024 Bentham Science Publishers
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2024-07-19
2025-01-31

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The Antihypertensive Potential of Aqueous extract of Peristrophe bivalvis (L.) Merr. is via Up-regulation of Cyclic Guanosine Monophosphate and Down-regulation of the Renin-angiotensin System
Cardiovasc Hematol Disord Drug Targets 24, 172 (2024); https://doi.org/10.2174/011871529X301799240715091918
/content/journals/chddt/10.2174/011871529X301799240715091918
/content/journals/chddt/10.2174/011871529X301799240715091918
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  • Article Type:     Research Article
Keyword(s): cyclic guanosine; endothelin-1; monophosphate; nitric oxide; nitric oxide synthase inhibitor; Peristrophe bivalvis; renin-angiotensin system

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