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2000
Volume 24, Issue 10
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

Background: Skin aging is a natural process resulting from intrinsic (hormonal and genetic) and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the skin to ultraviolet radiation, accounting for 80% of facial aging. Introduction: Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles, uneven tone, and dryness. Clinical signs of photoaging involve the presence of deeper wrinkles, rough texture, dyschromia and a greater loss of elasticity compared to chronological aging. Methods: This work reported several scientific articles that used computational techniques, such as molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to identify natural products and their derivatives against skin aging and photoaging. Results: The in silico analyses carried out by the researchers predicted the binding affinity and interactions of the natural products with the targets matrix metalloproteinase-1, matrix metalloproteinase- 3, matrix metalloproteinase-9 and tyrosinase. Furthermore, some studies have reported the stability of the protein-ligand complex and the physicochemical properties of the studied compounds. Finally, this research proposes promising molecules against the targets. Conclusion: Thus, studies like this one are relevant to guide new research related to skin aging and photoaging.

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/content/journals/cdt/10.2174/1389450124666230719105849
2023-08-01
2025-05-31
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  • Article Type:
    Review Article
Keyword(s): MMP-1; MMP-3; MMP-9; molecular docking; photoaging; Skin aging; tyrosinase
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