Skip to content
2000
Volume 20, Issue 1
  • ISSN: 1570-1638
  • E-ISSN: 1875-6220

Abstract

Background: One of the major problems with Brucella infections is its tendency to become chronic and recurrent, providing a hindrance to the management of this infection. It has been proposed that chronicity is greatly affected by a phenomenon called persistence in bacteria. Several mechanisms are involved in bacterial persistence, including the type II toxin-antitoxin system, the SOS and oxidative and stringent responses. Methods: In this in silico study, these persistence mechanisms in Brucella spp. were investigated. Results: The structure and the interactions between modules involved in these systems were designed, and novel peptides that can interfere with some of these important mechanisms were developed. Conclusion: Since peptide-based therapeutics are a new and evolving field due to their ease of production, we hope that peptides developed in this study, as well as the information about the structure and interactions of modules of persistence mechanisms, can further be used to design drugs against Brucella persister cells in the hope of restraining the chronic nature of Brucellosis.

Loading

Article metrics loading...

/content/journals/cddt/10.2174/1570163819666220805161821
2023-01-01
2024-11-01
Loading full text...

Full text loading...

/content/journals/cddt/10.2174/1570163819666220805161821
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test