Current Drug Delivery - Volume 20, Issue 1, 2023

Polymeric drug conjugates (PDCs) for cancer therapy have been a hot research topic for the past three decades. Successful examples of PDC conjugates have demonstrated sustained drug release action with decreased systemic toxicity and enhanced tumor retention effect (EPR) via active as well as passive targeting mechanisms. Therefore, the PDC approach has now become a keystone of the drug delivery system f Read More

Recently, polysaccharides have been proved to be an interesting drug delivery system as gene carriers, and natural polysaccharides have attracted more attention in the field of biomaterials due to their unique non-toxicity, good biocompatibility, and biodegradability. Compared with other polysaccharides, chitosan and dextran have more extensive and profound applications and can directly or indirectly deliver therapeutic Read More

Liposome nanoparticles (LNPs), as a promising platform in drug delivery, combine the advantages of both liposomes and inorganic/organic nanoparticles into a single system. Both liposomes and nanoparticles have demonstrated optimized drug efficacy in the clinic. LNPs are proven to be multifunctional systems and thus utilized in various research applications (e.g., spatiotemporal control of drug release, hyperthermia, Read More

Acne vulgaris is a universal multifactorial human skin condition of the pilosebaceous units. Although acne majorly prevails in teenagers, it is neither restricted to age group nor gender. Multifarious causative factors like Propionibacterium acnes, dysregulated sebum secretion, and androgens play an integral role in the manifestation of acne. Though abundant new chemical entities are convenient for acne therapy, none can treat t Read More

Background: Nowadays, biomedical research has been focusing on the design and development of new drug delivery systems that provide efficient drug targeting. The molecularly imprinted polymers (MIPs) have attracted wide interest and play an indispensable role as a drug carrier. Drug delivery systems based on MIPs have been frequently cited in the literature. They are cross-linked polymers that contain binding sites ac Read More

Introduction: Clarithromycin (antibiotic), due to its narrow absorption window in the gastrointestinal tract, was taken as a model drug. Materials and Methods: Focusing on the efficient drug delivery system, floating tablets that remain buoyant over gastric fluid for 24 hrs were produced by adopting the melt mold method using beeswax, gelucire, and oleic acid. To modulate the release pattern, a different concentration of 48 Read More

Background: Caffeine abundant in coffee has a strong excitation effect on the central nerve system (CNS). Methods: To combat the adverse effects of sleep deprivation on physical and mental health, this article designed a new nasal temperature-sensitive gel loaded with caffeine, whose effects of awakening and improving cognition in sleep-deprived rats were evaluated. Results: It was found that the caffeine thermo-sensitive in s Read More