Current Drug Delivery - Volume 19, Issue 4, 2022

Background: Electrospinning is developing rapidly from an earlier laboratory method into an industrial process. The clinical applications of this technique are approached in various ways through electrospun medicated nanofibers. Fast-dissolving oral drug delivery systems (DDSs) have promising commercial applications in the near future. Methods: Related papers have been investigated in this study, including the latest Read More

Abstract: Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery. This protocol allows maximal targeting effectiveness and therefore enhances therapeutic efficiency. In recent years, Mesoporous Silica Nanoparticles (MSNPs) have sparked interest in nanomedicine research community, partic Read More

Abstract: Compared to other nano polymers, dendrimers have novel three-dimensional, synthetic hyperbranched, nano-polymeric structures. These supramolecular dendritic structures have a high degree of significant surface and core functionality in the transportation of drugs for targeted therapy, specifically in host-guest response, gene transfer therapy, and imaging of biological systems. However, there are conf Read More

Background: Diverse pain killers used for the management of varied categories of pain are being misused in order to have extreme pleasant effects by a large number of populations. To overcome the misuse of prescription drugs, regulatory bodies have given stress on the development of abuse resistance. Methods: We studied numerous literatures: (1) Research and review papers including the guidelines for pain manage Read More

Background: Formulation of topical products for skin delivery that fulfill good formulation criteria has always been a challenge for pharmaceutical scientists. Despite the challenges, gelbased drug delivery offers some advantages such that it is non-invasive, painless, involves avoidance of the first-pass metabolism, and has satisfactory patient compliance. Objectives: In this study, C. odorata gel and quercetin gel (bioactive flav Read More

Aim: An active-passive dual-targeting gambogic acid HPMA Copolymer Coupling drug system with high efficiency, low toxicity and high selectivity was constructed. Methods: The gambogic acid HPMA copolymer coupling drug system was constructed and its structure was characterized. The cytotoxicity of gambogic acid HPMA copolymer was detected by MTT assay. The pharmacokinetics of gambogic acid HPMA copolymer w Read More

Background: The research and development of drugs for the treatment of central nervous system diseases faces many challenges at present. One of the most important questions to be answered is, how does the drug cross the blood-brain barrier to get to the target site for pharmacological action. Fluoxetine is widely used in clinical antidepressant therapy. However, the mechanism by which fluoxetine passes through the BBB Read More