Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Ken D. Johnstone; Manuela Dieckelmann; Michael P. Jennings; Istvan Toth; Joanne T. Blanchfield

doi:10.2174/1567201054367977

ISSN: 1567-2018
E-ISSN: 1875-5704

Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery
Authors: Ken D. Johnstone¹, Manuela Dieckelmann², Michael P. Jennings³, Istvan Toth⁴ and Joanne T. Blanchfield⁵
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¹ School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia. ² School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia. ³ School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia. ⁴ School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia. ⁵ School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia.
Source: Current Drug Delivery, Volume 2, Issue 3, Jul 2005, p. 215 - 222
DOI: https://doi.org/10.2174/1567201054367977
- Available online: 01 Jul 2005

Abstract

The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.

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2005-07-01

2025-05-17

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Article Type: Review Article

Keyword(s): chemo-enzymatic; drug targeting; endomorphin; glycopeptide; glycosyltransferase; oligosaccharide; peptide drug delivery; solid-phase synthesis

Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Abstract

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