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Volume 22, Issue 3
  • ISSN: 1567-2018
  • E-ISSN: 1875-5704

Abstract

Background

The regeneration of tissue damage involves a series of molecular and cellular events that can be mediated by various natural compounds. Recent studies have highlighted the anti-inflammatory, anti-ulcer, and skin-protecting properties of (Quince), which are mainly attributed to phenolic compounds. These compounds may have some drawbacks when targeting wound applications, including low bioavailability at the wound site. Moreover, to overcome these limitations, surfactant-based nanovesicular systems have been developed as carriers of such compounds for wound healing.

Objective

This study aimed to highlight the possible therapeutic potential of niosome-based hydrogel from Quince extract to stabilize and deliver the related bioactive compounds to full-thickness wounds in rats.

Methods

The niosomal hydrogel was prepared using a thin-film hydration method with the fruit extract (70% methanol). The formulation was optimized by evaluating size, zeta potential, dispersion index, and drug encapsulation efficiency. Full-thickness wounds were created on the dorsal cervical area of Wistar rats, and histopathological analysis of biopsy specimens was conducted on the 12th day of treatment.

Results

Under the study conditions, niosomal hydrogel displayed good physicochemical stability. Histopathological findings demonstrated that niosomal gel promoted angiogenesis, fibroblast maturation, collagen deposition, keratinization, and epidermal layer formation more effectively than control and hydrogel base. Furthermore, niosomal gel treatment markedly reduced inflammation. The total phenol concentration was determined to be 13.34 ± 0.90 mg gallic acid equivalents per gram of dried extract.

Conclusion

The niosomal hydrogel containing extract shows potential as a novel approach for wound healing, warranting further investigation in this field.

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2025-05-04

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References

  1. AsgariradH. EbrahimnejadP. MahjoubM.A. JalalianM. MoradH. AtaeeR. HosseiniS.S. FarmoudehA. A promising technology for wound healing; in-vitro and in-vivo evaluation of chitosan nano-biocomposite films containing gentamicin.J. Microencapsul.202138210010710.1080/02652048.2020.185178933245001
     [Google Scholar]
  2. RainaR. ParwezS. VermaP. PankajN. Medicinal plants and their role in wound healing.Vet Scan20083117
     [Google Scholar]
  3. AliM. Abdel MotaalA. AhmedM.A. AlsayariA. El-GazayerlyO.N. An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system.Drug Deliv.201825141742510.1080/10717544.2018.143197729382233
     [Google Scholar]
  4. TiwariR. PathakK. Local drug delivery strategies towards wound healing.Pharmaceutics202315263410.3390/pharmaceutics1502063436839956
     [Google Scholar]
  5. BehyariM. ImaniR. KeshvariH. Evaluation of silk fibroin nanofibrous dressing incorporating niosomal propolis, for potential use in wound healing.Fibers Polym.20212282090210110.1007/s12221‑021‑0973‑2
     [Google Scholar]
  6. JoshiS. WhiteR. SahuR. DennisV.A. SinghS.R. DennisV.A. SinghS.R. Comprehensive screening of drug encapsulation and co-encapsulation into niosomes produced using a microfluidic device.Processes20208553510.3390/pr8050535
     [Google Scholar]
  7. LiuP. ChenG. ZhangJ. A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives.Molecules2022274137210.3390/molecules2704137235209162
     [Google Scholar]
  8. MomekovaD.B. GuglevaV.E. PetrovP.D. Nanoarchitectonics of multifunctional niosomes for advanced drug delivery.ACS Omega2021649332653327310.1021/acsomega.1c0508334926878
     [Google Scholar]
  9. RajeraR. NagpalK. SinghS.K. MishraD.N. Niosomes: A controlled and novel drug delivery system.Biol. Pharm. Bull.201134794595310.1248/bpb.34.94521719996
     [Google Scholar]
  10. UnR.N. BarlasF.B. YavuzM. Ag SeleciD. SeleciM. GumusZ.P. GulerE. DemirB. CanM. CoskunolH. TimurS. Phyto-niosomes: In vitro assessment of the novel nanovesicles containing marigold extract.Int. J. Polym. Mater.2015641792793710.1080/00914037.2015.1030663
     [Google Scholar]
  11. MuzzalupoR. TavanoL. Niosomal drug delivery for transdermal targeting: recent advances. Res. Rep. Transdermal. Drug Deliv.201542333
     [Google Scholar]
  12. FarmoudehA. ShokoohiA. EbrahimnejadP. Preparation and evaluation of the antibacterial effect of chitosan nanoparticles containing ginger extract tailored by central composite design.Adv. Pharm. Bull.202011464365010.34172/apb.2021.07334888211
     [Google Scholar]
  13. RameshkM. SharififarF. MehrabaniM. PardakhtyA. FarsinejadA. MehrabaniM. Proliferation and in vitro wound healing effects of the microniosomes containing Narcissus tazetta L. bulb extract on primary human fibroblasts (HDFs).Daru2018261314210.1007/s40199‑018‑0211‑730209758
     [Google Scholar]
  14. JamaludinR. DaudM.N. SulongR.R.S. YaakobH. AzizA.A. KhamisS. Md SallehL. Andrographis paniculata-loaded niosome for wound healing application: Characterisation and in vivo analyses.J. Drug Deliv. Sci. Technol.2021632310242710.1016/j.jddst.2021.102427
     [Google Scholar]
  15. AliaslF. ToliyatT. MohammadiA. MinaeeB. SamadiN. AliaslJ. SadeghpourO. Medicinal properties of Cydonia oblonga mill fruit (pulp and peel) in Iranian traditional medicine and modern phytothrapy.Tradit. Integr. Med201613122128
     [Google Scholar]
  16. AlanZ. ÖzgüldüH. ErdalM.S. BucakA.Y. ÜresinA.Y. AkalınE. Evaluation of clinical trials of the plants, which have ethnobotanical uses for skin disorders in Turkey: A review.Clin. Phytosci.2021717910.1186/s40816‑021‑00316‑x
     [Google Scholar]
  17. Al-SnafiA.E. The medical importance of Cydonia oblonga-A review.IOSR J. Pharm.2016668799
     [Google Scholar]
  18. KhoubnasabjafariM. JouybanA. A review of phytochemistry and bioactivity of quince (Cydonia oblonga Mill.).J. Med. Plants Res.201151635773594
     [Google Scholar]
  19. RochaH.K.M. GuzmánR.N.E. InfanteG.J.A. LaredoG.R.F. PérezL.M. JiménezM.M.R. Phenolic acids and flavonoids in acetonic extract from quince (Cydonia oblonga Mill.): Nutraceuticals with antioxidant and anti-inflammatory potential.Molecules2022278246210.3390/molecules2708246235458657
     [Google Scholar]
  20. AshrafM.U. MuhammadG. HussainM.A. BukhariS.N.A. Cydonia oblonga M., a medicinal plant rich in phytonutrients for pharmaceuticals.Front. Pharmacol.2016716310.3389/fphar.2016.0016327445806
     [Google Scholar]
  21. MinaiyanM. GhannadiA. EtemadM. MahzouniP. A study of the effects of Cydonia oblonga Miller (Quince) on TNBS-induced ulcerative colitis in rats.Res. Pharm. Sci.20127210311023181087
     [Google Scholar]
  22. ShinomiyaF. HamauzuY. KawaharaT. Anti-allergic effect of a hot-water extract of quince (Cydonia oblonga).Biosci. Biotechnol. Biochem.20097381773177810.1271/bbb.9013019661701
     [Google Scholar]
  23. KorkinaL.G. Mikhal’chikE. SuprunM.V. PastoreS. TosoD.R. Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides.Cell. Mol. Biol.2007535849117543237
     [Google Scholar]
  24. ChenX. YueZ. WinbergP.C. DinoroJ.N. HayesP. BeirneS. WallaceG.G. Development of rhamnose-rich hydrogels based on sulfated xylorhamno-uronic acid toward wound healing applications.Biomater. Sci.2019783497350910.1039/C9BM00480G31290861
     [Google Scholar]
  25. ChivteP.S. PardhiV.S. JoshiV.A. RaniA. A review on therapeutic applications of phytosomes.J. Drug Deliv. Ther.201775172110.22270/jddt.v7i5.1513
     [Google Scholar]
  26. AshooriF. FakharM. GoliH.R. MirzaeeF. FaridniaR. KalaniH. ShahaniS. Antileishmanial and antibacterial activities of the hydroalcoholic extract of Rhus coriaria L.Ann. Parasitol.202062215716332531148
     [Google Scholar]
  27. SankhyanA. PawarP.K. Metformin loaded non-ionic surfactant vesicles: Optimization of formulation, effect of process variables and characterization.Daru2013211710.1186/2008‑2231‑21‑723351604
     [Google Scholar]
  28. ShirsandS.B. KananiK.M. KeerthyD. NagendrakumarD. ParaM.S. Formulation and evaluation of Ketoconazole niosomal gel drug delivery system.Int. J. Pharm. Investig.20122420120710.4103/2230‑973X.10700223580936
     [Google Scholar]
  29. El-KasedR.F. AmerR.I. AttiaD. ElmazarM.M. Honey-based hydrogel: In vitro and comparative in vivo evaluation for burn wound healing.Sci. Rep.201771969210.1038/s41598‑017‑08771‑828851905
     [Google Scholar]
  30. MancaM.L. CencettiC. MatricardiP. CastangiaI. ZaruM. SalesO.D. NacherA. ValentiD. MaccioniA.M. FaddaA.M. ManconiM. Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration.Int. J. Pharm.2016511119820410.1016/j.ijpharm.2016.07.00927418567
     [Google Scholar]
  31. SharifiF. JahangiriM. EbrahimnejadP. Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation.Artif. Cells Nanomed. Biotechnol.202149136738010.1080/21691401.2021.190739333851564
     [Google Scholar]
  32. SohrabiS. HaeriA. MahboubiA. MortazaviA. DadashzadehS. Chitosan gel-embedded moxifloxacin niosomes: An efficient antimicrobial hybrid system for burn infection.Int. J. Biol. Macromol.20168562563310.1016/j.ijbiomac.2016.01.01326794314
     [Google Scholar]
  33. AbdelbaryA.A. AbouGhalyM.H.H. Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: Application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study.Int. J. Pharm.20154851-223524310.1016/j.ijpharm.2015.03.02025773359
     [Google Scholar]
  34. Sadeghi-GhadiZ. BehjouN. EbrahimnejadP. MahkamM. GoliH.R. LamM. NokhodchiA. Improving antibacterial efficiency of curcumin in magnetic polymeric nanocomposites.J. Pharm. Innov.2023181132810.1007/s12247‑022‑09619‑z
     [Google Scholar]
  35. TjahyadiD. PertiwiM. DjuwantonoT. WathoniN. AnwarR. Organoleptic, pH stability, viscosity, and sterility of sonohysterosalpingography hydroxy propyl cellulose-based gel (As an alternative media for examination of hystero-foam sonosalpingography).Am. J. Res. Commun.2015351027
     [Google Scholar]
  36. JainV. ThakurM. Development and characterization naproxen gel bearing eucalyptus oil for topical delivery.Appl. Med. Res.2015211510.47363/AMR/2015(2)118
     [Google Scholar]
  37. JainA. DevedaP. VyasN. ChauhanJ.K. KhambeteH. JainS. Development of antifungal emulsion based gel for topical fungal infection.Int. J. Pharm. Res20112121822
     [Google Scholar]
  38. Talebpour AmiriF. MirzaeeF. HasanzadehS.N. EnayatifardR. ShahaniS. Therapeutic potential of ointment containing methanol extract of Lamium album L. on cutaneous wound healing in rats.Faslnamah-i Giyahan-i Daruyi20212079728410.52547/jmp.20.79.72
     [Google Scholar]
  39. Hanafi HanafiN. Talebpour AmiriF. ShahaniS. EnayatifardR. GhasemiM. KarimpourA.A. Licorice cream promotes full-thickness wound healing in Guinea pigs.J. Pharm. Res.2018221849410.12991/jrp.2018.81
     [Google Scholar]
  40. AbramovY. GoldenB. SullivanM. BotrosS.M. MillerJ.J.R. AlshahrourA. GoldbergR.P. SandP.K. Histologic characterization of vaginal vs. abdominal surgical wound healing in a rabbit model.Wound Repair Regen.2007151808610.1111/j.1524‑475X.2006.00188.x17244323
     [Google Scholar]
  41. BaziZ. BertacchiM. AbasiM. YeganehM.S. SoleimaniM. WagnerN. GhanbarianH. Rn7SK small nuclear RNA is involved in neuronal differentiation.J. Cell. Biochem.201811943174318210.1002/jcb.2647229091296
     [Google Scholar]
  42. HeX. ZhangC. AmirsaadatS. JalilA.T. KadhimM.M. AbasiM. PilehvarY. Curcumin-loaded mesenchymal stem cell–derived exosomes efficiently attenuate proliferation and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.Appl. Biochem. Biotechnol.20231951516710.1007/s12010‑022‑04090‑535932371
     [Google Scholar]
  43. ObeidM.A. KhadraI. AljabaliA.A.A. AmawiH. FerroV.A. Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery.Int. J. Pharm. X2022410013710.1016/j.ijpx.2022.10013736386005
     [Google Scholar]
  44. BriugliaM.L. RotellaC. McFarlaneA. LamprouD.A. Influence of cholesterol on liposome stability and on in vitro drug release.Drug Deliv. Transl. Res.20155323124210.1007/s13346‑015‑0220‑825787731
     [Google Scholar]
  45. RitwisetA. KrongsukS. JohnsJ.R. Molecular structure and dynamical properties of niosome bilayers with and without cholesterol incorporation: A molecular dynamics simulation study.Appl. Surf. Sci.2016380233110.1016/j.apsusc.2016.02.092
     [Google Scholar]
  46. KhanD.H. BashirS. FigueiredoP. SantosH.A. KhanM.I. PeltonenL. Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes.J. Drug Deliv. Sci. Technol.201950273310.1016/j.jddst.2019.01.012
     [Google Scholar]
  47. KhiljeeT. AkhtarN. KhiljeeS. Evaluation of Pyrus communis and Cydonia oblonga fruit extract loaded emulgel on skin pliancy by using Cutometer.Pak. J. Pharm. Sci.20223541173117936218095
     [Google Scholar]
  48. MinaiyanM. ParvanM. SajjadiS-E. Protective effect of two extracts of Cydonia oblonga miller (Quince) fruits on gastric ulcer induced by indomethacin in rats.Int. J. Prev. Med.2017815810.4103/ijpvm.IJPVM_124_1728900537
     [Google Scholar]
  49. GrygorievaO. KlymenkoS. VergunO. MňahončákováE. BrindzaJ. TerentjevaM. IvanišováE. Evaluation of the antioxidant activity and phenolic content of Chinese quince (Pseudocydonia sinensisSchneid.) fruit.Acta Sci. Pol. Technol. Aliment.2020191253610.17306/J.AFS.073832227695
     [Google Scholar]
  50. IslamF. AfzaalM. ChauhanA. ImranA. ShahidS. AsgharA. ZahoorT. ZahraM.S. ShahA.M. Chemical and biological properties of Cydonia oblonga L. flour: A concurrent review.Int. J. Food Prop.20232611167117610.1080/10942912.2023.2205059
     [Google Scholar]
  51. ChenW.C. LiouS.S. TzengT.F. LeeS.L. LiuI.M. Effect of topical application of chlorogenic acid on excision wound healing in rats.Planta Med.201379861662110.1055/s‑0032‑132836423568627
     [Google Scholar]
  52. OlennikovD.N. ChirikovaN.K. TsyrenzhapovA.V. Phenylpropanoids from Parasenecio hastatus (Compositae) and their wound-healing activity.Russ. J. Bioorganic Chem.20214771411141710.1134/S106816202107013X
     [Google Scholar]
  53. BojilovD. ManolovS. AhmedS. DagnonS. IvanovI. MarcG. OnigaS. OnigaO. NedialkovP. MollovaS. HPLC analysis and in vitro and in silico evaluation of the biological activity of polyphenolic components separated with solvents of various polarities from Helichrysum italicum. Molecules20232817619810.3390/molecules2817619837687028
     [Google Scholar]
  54. OryanA. AlemzadehE. MoshiriA. Role of sugar-based compounds on cutaneous wound healing: what is the evidence?J. Wound Care201928Sup3bs13s2410.12968/jowc.2019.28.Sup3b.S1330900931
     [Google Scholar]
  55. HopurH. AsrorovA. QinglingM. YiliA. AyupbekA. NannanP. AsiaH. HPLC Analysis of polysaccharides in Quince (Cydonia Oblonga Mill. var. maliformis) fruit and PTP1B inhibitory activity.Nat. Prod. J.20111214615010.2174/2210315511101020146
     [Google Scholar]
  56. WeiZ. HuangL. CuiL. ZhuX. Mannose: Good player and assister in pharmacotherapy.Biomed. Pharmacother.202012911042010.1016/j.biopha.2020.11042032563989
     [Google Scholar]
  57. KössiJ. PeltonenJ. EkforsT. NiinikoskiJ. LaatoM. Effects of hexose sugars: Glucose, fructose, galactose and mannose on wound healing in the rat.Eur. Surg. Res.1999311748210.1159/00000862310072613
     [Google Scholar]
  58. LiuH.M. TangW. LeiS.N. ZhangY. ChengM.Y. LiuQ.L. WangW. Extraction optimization, characterization and biological activities of polysaccharide extracts from Nymphaea hybrid. Int. J. Mol. Sci.20232410897410.3390/ijms2410897437240320
     [Google Scholar]
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Niosome-Based Hydrogel of Quince Extract: A Promising Strategy for Expedited Full-thickness Wound Healing in Rat
Curr. Drug Deliv. 22, 358 (2025); https://doi.org/10.2174/0115672018282735240528072715
/content/journals/cdd/10.2174/0115672018282735240528072715
/content/journals/cdd/10.2174/0115672018282735240528072715
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  • Article Type:     Research Article
Keyword(s): anti-ulcer; drug delivery systems; niosome; phenol; Quince; rat; wound healing

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