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- Volume 8, Issue 2, 2013
Current Clinical Pharmacology - Volume 8, Issue 2, 2013
Volume 8, Issue 2, 2013
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Multifaceted Individualities in Pharmacological Treatments of Obesity
By Marko BobanSimply put, there is no cure for obesity. Pharmaceuticals that induce weight loss of extent of at least 5% from baseline are applied and tested as the weight loosing drugs. Available guidelines include recommendations that pharmacologic treatment of obesity may be offered to patients with BMI > 30 kg/m2; or BMI >27 kg/m2 and obesity related comorbidity. Both categories cumulatively include essential boundary condition o Read More
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The Implications of Iodine and its Supplementation During Pregnancy in Fetal Brain Development
Authors: Manel Puig-Domingo and Lluis VilaIodine is an essential trace element for life. Its biological effects are a consequence of its incorporation to the thyroid hormones, which play a crucial role in fetal organogenesis, and in particular in brain development. This takes place during early gestation and involves delicate targeting throughout the central nervous system, including adequate neuronal growth, migration and myelinization at different sites, such as the c Read More
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The Concept of Titration can be Transposed to Fluid Management. But does is Change the Volumes? Randomised Trial on Pleth Variability Index During Fast-Track Colonic Surgery
Authors: Patrice Forget, Fernande Lois, Alex Kartheuser, Daniel Leonard, Christophe Remue and Marc De KockBackground: The concept of drug titration emerged recently for intraoperative fluid administration during Fast-Track colonic surgery to avoid hypovolemia as well as excessive crystalloid administration. The Pleth Variability Index (PVI) is an oximeter-derived parameter. It allows a continuous monitoring of the respiratory variation of the perfusion index. Objective: To investigate if applying the concept of fluid titratio Read More
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Globalization of Clinical Trials – Where are We Heading?
The last decade has witnessed a greater transparency in clinical research with the advent of clinical trial registries. The aim of the study was to describe the trends in the globalization of clinical trials in the last five years. We performed an internet search using the WHO International clinical trials registry platform (WHO ICTRP) to identify the clinical trials conducted from January 2007 to December 31, 2011 among 25 countri Read More
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An Evidence-Based Review of Risk-Reductive Strategies for Osteonecrosis of the Jaws Among Cancer Patients
Purpose: Bone antiresorptive treatment is associated with osteonecrosis of the jaws. Interventions used to treat this complication are diverse, controversial, and largely empirical but certain risk factors could help in its avoidance. The aim of this evidence-based review is to elucidate any interventions that are effective in reducing the risk for development of ONJ in cancer patients receiving bone antiresorptive therapy and Read More
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The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice
Authors: Philipp Y. Maximov, Theresa M. Lee and V. Craig JordanSelective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen receptor agonists or antagonists. These drugs have been intensively studied over the past decade and have proven to be a highly versatile group for the treatment of different conditions associated with postmenopausal women's health, including hormone resp Read More
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Challenging the Evidence Based Medicine Principles Among Clinical Obesity Treatments
Authors: Bojan Miletic, Marko Boban, Igor Prpic and Zeljko JovanovicObesity is among the greatest health problems worldwide. However, there is a certain lack in regard to objective evidence-based clinical therapeutic algorithms. The conservative therapy (lifestyle changes, pharmacotherapy) often fails to attain clinically significant weight lost. For this reason, more effective forms of treatment were developed (for example bariatric surgery or newly emerging field of endoscopic gastro Read More
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Obesity in the Cardiovascular Continuum
More LessA higher prevalence of coronary heart disease, cardiac and overall mortality is associated with obesity. The development of obesity appears in different adaptations in the morphology of cardiac structure and function. Obesity causes eccentric hypertrophy and changes in diastolic function of left ventricle. A systolic on diastolic heart dysfunction results from the breakdown of compensatory pace to raised wall stress and dila Read More
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Reported Dose as a Measure of Drug Exposure after Paracetamol Overdose in Children
Authors: Katharine J. Rutter, Tim Ubhi, Dominic Smith, Gary Kitching and W. Stephen WaringThe decision to administer antidote after paracetamol overdose is based on the extent of drug exposure, and this often relies on the reported dose. Few data exist concerning the validity of this approach in children. The present observational study sought to examine the relationship between the reported dose and paracetamol concentrations in patients aged ≤18 years admitted to York Hospital between October 2008 and Novem Read More
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Effect of Probiotic or Prebiotic Supplementation on Antibiotic Therapy in the Small Intestinal Bacterial Overgrowth: A Comparative Evaluation
Bacterial intestinal overgrowth syndrome (SIBO) treatment is based on antibiotics. Probiotics have been shown to give similar results, whilst no study is available about prebiotics. This study evaluated the addition of probiotics or prebiotics to antibiotics on SIBO symptoms in a 6-month follow-up. We enrolled 40 patients (14 males and 26 females) reporting abdominal compliant without gastrointestinal diseases/alarm symptom Read More
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