Current Clinical Pharmacology - Volume 4, Issue 3, 2009

In this paper errors in variables methods for fitting straight lines to data are reviewed. In these methods the x and y variables are both assumed to be subject to measurement error and not, as in simple least squares linear regression, just one of them. The methods are described in a unified context using the statistical principle of the method of moments. Guidance is given on the choice of an appropriate method of estimatin Read More

Normal pregnancy is associated with significant hemodynamic changes in the cardiovascular system in order to meet the metabolic demands of mother and fetus. These changes include increased cardiac output, decreased vascular resistance, and vascular remodeling in the uterine and systemic circulation. Preeclampsia (PE) is a major complication of pregnancy characterized by proteinuria and hypertension. Several ris Read More

This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

The aim of this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified effects. Strong scientific evidence is available for Rhodiola rosea SHR-5 extract, which improved attention, cognitive function and mental performance in fatigue and in chronic fatigue syndrome. Good scientific evidence has been doc Read More

Drug discovery is the main flag ship of the pharmaceutical industry in order to ensure that innovations constantly occur in the identification and development of novel therapeutic options for the management of diseases. Recently, research trends that take advantage of the safety and efficacy of marketed products by combining such products with other agents to influence certain clinical pharmacology attribute(s) have Read More

Aim: Impact of gender on aminoglycoside induced nephrotoxicity is still controversial and inconclusive. The objective of this study was to investigate the nephrotoxic potential of amikacin (AK) and gentamicin (GM) in male and female hospitalized patients. Methodology: A one-year, non-interventional prospective study of patients administered either GM or AK. The study was carried out at the internal medicine departme Read More

Objectives: To assess the prevalence of the metabolic syndrome (MetS) in overweight/obese children and adolescents of an out-patient clinic, and to compare two definitions of MetS in adolescents. Methods: In total, 528 overweight/obese children (3-16 years), of multi-ethnic origin, underwent an oral glucose tolerance test, blood collections and anthropometric measurements. In children <10 years, MetS was assessed accordin Read More

Recent Adcances and Developments in Treatment Strategies Against Pancreatic Cancer. Rosemary A. Fryer, Christine Galustian and Angus G. Dalgleish. Original Citation: Curr Clin Pharm 2009; 4(2): 102-112. During the preparation of the manuscript, on the title page, the last author's surname was misspelled. The correct author's name appears above.