Current Clinical Pharmacology - Volume 11, Issue 3, 2016

Background: Post-operative atrial fibrillation (POAF) is a major and frequent complication occurring after cardiac surgery, contributing to prolonged intensive care and hospital stays and is associated with several cardiovascular complications. The exact mechanisms and signaling pathways involved in the development of POAF seem to be multifactorial and remain to date incompletely understood. β-blockers and amiodarone Read More

Background: The toxicity of lead and its compounds is well known, causing anemia by inhibiting the synthesis of porphyrins. The neurotoxic effects, particularly in the young, alter the structure of cell membranes and DNA. Chronic exposure to lead has adverse effects on the body by disrupting the mechanisms of energy production and tissue damage, in particular in its links with thiol groups and competition for binding sites with Read More

Background: Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. Numerous efforts have been put forward to find ways to overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have be Read More

Endothelin-1, (ET-1, EDN1) is an endogenous polypeptide which demonstrates dominant vasoconstriction activity and mitogenic effect. It has positive inotropic and chronotropic effects on the heart, stimulates the sympathetic and the renin-angiotensin-aldosterone systems and modifies homeostasis. The human ET-1 gene which consists of 6836 nucleotides located on chromosome 6p23-p24 produces Pre-pro-ET-1, which Read More

Remineralizing agents represent a new frontier in dentistry. They may be classified as fluoride agents, calcium and phosphate based agents, herbal agents or combinations. The modes of delivery of remineralizing agents may be as dentifrices, mouth rinses, lozenges or chewing gums. The applications of remineralizing agents may be extrapolated to virtually every branch of dentistry ranging from pediatric to geriatric dentistry.

Background: There is still speculative data regarding the role of spinal dopaminergic neurotransmission in restless leg syndrome (RLS). Methods: We evaluated the therapeutic role of pramipexole in a patient with cervical disc prolapsus who exceptionally presented with neck restlessness. Results: We have found that pramipexole leads to a significant improvement in restlessness symptoms in the neck region. Discussion: Th Read More