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Exploring Potential Bifunctional Peptides with Anti-tyrosinase and Antioxidant Activities from Porphyra Protolysate Using in Silico Analysis
Authors: Si-Bo Huang, Pei-Xia Feng, Liu-ying Li, Hong-Hui Guo and En-Qin XiaAvailable online: 29 April 2025More LessBackground Extracts from Porphyra have been detected to have antioxidant activity and tyrosinase (TYR) inhibitory activity. However, bioactive peptides (BPs) released from Porphyra proteins (PPs) have not been comprehensively reported. Objective The aim of this study is to rapidly identify bifunctional peptides with antioxidant and TYR inhibitory activities from a large number of digested peptides from PPs. Methods In this st Read More
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Exploring the Active Ingredients and Core Targets of Erxia Decoction in the Treatment of Sleep Disorder by Integration of Network Pharmacology and Proteomics
Authors: Bo Jiang, Huiran Yang, Fei Zhou, Huijun Qu, Xueqian Hu and Zhanwen LiuAvailable online: 29 April 2025More LessAims For clarifying the “multi genes and multi targets” characteristic of the treatment of Erxia Decoction (EXD), the aim of this study was to employ network pharmacology technology to perform cluster analysis on selected EXD targets. Background EXD, a famous Chinese herbal prescription, consisting of Pinelliae Rhizoma (PR) and Prunellae Spica (PS), was mainly used to treat sleep disorder (SLD). Objective Using network ph Read More
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Shenhuang Liuwei Powder Alleviates Streptozotocin-Induced Diabetic Ulcers in Rats through the Inhibition of the AGE/RAGE Signaling Pathway and Promotion of Antibacterial Activity and Angiogenesis via Activation of the PI3K/Akt/eNOS/HIF-1α Pathway
Authors: Jun Li, Qian Zhang, Shengnan Li, Shu Wang, Fengye Zhou, Haifeng Zhang, and and Jianping ChenAvailable online: 24 April 2025More LessAims and Objective Shenhuang Liuwei powder (SHLWP) is frequently used to treat diabetic ulcers (DUs), but its mechanism of action remains poorly understood. This study aimed to identify the active compounds and mechanisms by which SHLWP alleviates DUs. Methods The chemical components of SHLWP were analyzed using high-resolution mass spectrometry (HRMS). Network pharmacology based on HRMS data id Read More
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Identification of the Role of Necroptosis-Related Genes in the Oxidative Damage of Lens Epithelial Cells and Validation in Ultraviolet B-induced Cataract in Rats
Authors: Yongshun Liang, Qingqiao Gan, Xin Zhong, Tian Lan, Yingqin Yang and Hao LiangAvailable online: 17 April 2025More LessIntroductionThe specific role of necroptosis in the pathogenesis of cataracts remains unclear. This study aimed to identify and validate the genes related to necroptosis in the development of cataracts through bioinformatics analysis.MethodWe utilized RNA sequencing data (GSE161701) from the Gene Expression Omnibus (GEO) database and employed R software to perform differential expression analysis of necroptosis-relat Read More
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Xuebijing Alleviates Microglial Activation after Traumatic Brain Injury via Regulation of NF-κB Pathway: Network Pharmacology and Experimental Validation
Authors: Hongran Fu, Xiaoyu Wang, Xuelin Mo, Jingwei Li and Dongkai GuoAvailable online: 15 April 2025More LessObjective Xuebijing (XBJ) injection, a Traditional Chinese medicine (TCM) widely used in China for treating sepsis and multiple organ dysfunction, has shown neuroprotective effects in traumatic brain injury (TBI). However, the mechanisms underlying these effects remain unclear. This study aims to elucidate the neuroprotective and pharmacological molecular mechanisms of XBJ and its active monomer, Hydroxy-safflor yellow A (HS Read More
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The Regulatory Effects of Electroacupuncture on the Intestinal Flora of Mice with Ulcerative Colitis
Authors: Xinyu Gao, Enfan Xiao, Shaohui Geng, Haixu Jiang, Hesong Wang, Yuxin Zhao, Jiaxin Xie, Guangrui Huang and Wenrui JiaAvailable online: 07 April 2025More LessIntroduction This study aimed to investigate the modulation of intestinal flora by electroacupuncture in a murine ulcerative colitis (UC) model, with a focus on analyzing microbial taxa and identifying key regulatory targets and pathways. Methods A UC model was established in mice using 5% dextran sodium sulfate (DSS). Electroacupuncture was applied at bilateral “Shangjuxu” (electrostimulation) and “Tianshu” (manual acup Read More
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Curcumin Regulating Primordial Follicle Initiation by Restoring the Oxidative-antioxidant Balance
Authors: Wanjing Li, Jinbang Xu, Dan Shi, Jingyi Wang, Tao Liu, Juan Yang and Disi DengAvailable online: 07 April 2025More LessBackground Diminished ovarian reserve (DOR) is accompanied by abnormal initiation and development of primordial follicles. Reporting that curcumin can protect the ovarian reserve, we used rats as a model to explore the regulatory mechanism of curcumin on primordial follicle priming. Objective Curcumin restores the ovarian microenvironment of DOR model rats by AMPK/SIRT 1 signaling pathway, thus regulating the ini Read More
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Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways
Authors: Caiyuzhen Zhang, Yuanwen Dai, Yong Chen, Bo Cao, Jinbing An and Wei PangAvailable online: 27 March 2025More LessBackground Atherosclerosis (AS) is a leading cause of cardiovascular diseases, characterized by lipid accumulation in arterial walls. The gene Ephx2, which encodes soluble epoxide hydrolase (sEH), is implicated in AS development, but its precise mechanisms and therapeutic potential are not fully understood. Objectives This study aimed to analyze gene expression data from low-density lipoprotein receptor knockout (LDLR Read More
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Astragalosides Promote MH7A Cell Apoptosis by Suppressing WTAP-mediated m6A Methylation of TRAIL-DR4
Authors: Xiaoya Cui, Linhui Zhang, Huimei Chen and Hui JiangAvailable online: 25 March 2025More LessBackground Astragaloside (AST), a natural saponin extracted from Astragalus membranaceus (Fisch.) Bunge., has been consistently utilized in the treatment of rheumatoid arthritis (RA). N6-methyladenosine (m6A), the most prevalent modification of mRNA, is associated with the progression of various diseases, including RA. Nonetheless, the effects of AST on m6A modification in RA remain to be elucidated. Methods The MH7A c Read More
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Jiawei Danggui Buxue Decoction Reduces Apoptosis and EMT of Renal Interstitial Fibrosis by Regulating JAK2/STAT3 Signaling Pathway
Authors: Xin Jiang, Yinghang Wang, Saiyue Qiu, Lu Tang, Meixiu Luo and Zhi PanAvailable online: 11 March 2025More LessBackground Renal interstitial fibrosis (RIF) is the primary pathological progression in chronic kidney disease (CKD). Given the constraints related to cost and adverse effects of current treatments, it is crucial to explore novel and efficacious therapeutic strategies. The purpose of this study was to elucidate the potential of Jiawei Danggui Buxue Decoction (JDBD) to reduce apoptosis and epithelial-mesenchymal transition (EMT) in RIF Read More
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GLI3 is Inhibited by miR-143-3p and Attenuates Septic-induced Lung Injury and Inflammation by Targeting SFRP1
Authors: Minqing Ma, Haixia Han, Xiaoyan Luo, Jiakai Lin and Bin SunAvailable online: 10 March 2025More LessObjectives Transcription factors (TF) are the central regulatory hubs of signaling pathways in eukaryotic cells. Here, we explored the abnormal expression of TF in septic-induced lung injury by sequencing. Methods The levels of target proteins were detected using Western Blot and Elisa. Cell function was evaluated using CCK8 and transwell assays. A double luciferase reporter assay was performed to detect interactions betwe Read More
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The Anti-PEDV Effects and Mechanisms of Forsythia Essential Oil Based on Network Pharmacology and Experimental Validation
Authors: Ruiping Liang, Jianbo Guo, Kai Li, Xuan Wang, Xiaoxiao Ge, Jinhui Wang, Jing Sun, Chongbo Zhao, Huanxian Shi, Rongxia Qiao, Hongqing Zheng and Xiaofei ZhangAvailable online: 10 March 2025More LessObjective Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae, is responsible for acute diarrhea, vomiting, and dehydration, which can lead to high mortality in neonatal piglets. Previous research has indicated the antiviral potential of forsythia essential oil (FEO); however, its active components and mechanisms of action remain inadequately defined. This study aims to investigate the antiviral effects of FEO Read More
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Computational Study for Preparation of Benzoimidazo[1,2-a]pyrimidines from Reaction of Benzaldehyde, Indanedione and 1H-benzo[d]imidazol-2-amine
Authors: Yas Zibaei, Leila Zare Fekri and Mohammad NikpassandAvailable online: 03 March 2025More LessBackground Benzoimidazo[1,2-a]pyrimidines are important compounds that have many useful effects in the body. They can help fight cancer, fungal infections, inflammation, and viruses. They can also help with various other health conditions. They can act as antineoplastic, antitubercular, parasitical activity, benzodiazepine receptor agonists, calcium channel blockers, potent P38 MAP kinase inhibitors, TIE-2 and/or VEGFR2 i Read More
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Dry Powder Inhaler of Sustained-Release Microspheres Containing Glycyrrhizin: Factorial Design and Optimization
Authors: Arpita Chakraborty, Riya Mahar and Nidhi NainwalAvailable online: 28 February 2025More LessBackground Glycyrrhizin is a saponin glycoside of the liquorice plant. It is commonly used to treat respiratory problems. Inhalable glycyrrhizin formulation in asthma can be a good alternative for widely used inhaled corticosteroids that exhibit side effects upon long-term use. Aim Asthma is a major and prevalent respiratory disease. However, the rate of drug development in this arena is quite slow, as indicated by merely fou Read More
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Revealing the Mechanism of Buzhong Yiqi Tang in Ameliorating Autoimmune Thyroiditis via the Toll-like Receptor Pathway
Authors: Zhuo Zhao, Jiayun Li, Donglin Liu, Hao Gao, Zhe Jin, Zhimin Wang, Yiran Chen, Si Chen, Ziyu Liu and Xiao YangAvailable online: 28 February 2025More LessObjective Autoimmune thyroiditis (AIT) is one of the most common autoimmune diseases and often causes hypothyroidism in patients. As a traditional formulation in my country, Buzhong Yiqi decoction (BZYQD) has significant effects in improving clinical symptoms of AIT and reducing autoantibody titers, but its specific mechanism of action needs to be further explored. The purpose of this study was to explore the effec Read More
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Agaricus blazei Murill Extract (FA-2-b-β) Induces Ferroptosis in Diffuse Large B-Cell Lymphoma via the Nrf2/Ho-1 Pathway
Authors: Rong Li, Dan Huang, Along Wu and Yanqin SunAvailable online: 28 February 2025More LessIntroduction Ferroptosis is a recently identified iron-dependent programmed cell death closely linked to the progression of diffuse large B-cell lymphoma (DLBCL). While studies have shown that FA-2-b-β extracted from Agaricus blazei Murill affects various malignancies, its specific role in modulating ferroptosis in DLBCL and the underlying mechanisms are not yet clear. Objectives: This study aims to elucidate the anticanc Read More
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20D-Dynamic Representation of Protein Sequences Combined with K-means Clustering
Authors: Dorota Bielińska-Wąż, Piotr Wąż and Agata BłaczkowskaAvailable online: 26 February 2025More LessObjective The objective of this research is to demonstrate that alignment-free bioinformatics approaches are effective tools for analyzing the similarity and dissimilarity of protein sequences. All numerical parameters representing sequences are expressed analytically, ensuring precision, clarity, and efficient processing, even for large datasets and long sequences. Additionally, a novel approach for identifying previously un Read More
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Advances in Targeting Neutrophil Extracellular Traps as a Promising Approach for Breast Cancer Treatment
Authors: Jiale Mi, Jiani Guo, Kang Kang, Shiqi Wang and Mingde HuangAvailable online: 26 February 2025More LessNeutrophils release neutrophil extracellular traps (NETs), a reticular structure mainly composed of antimicrobial peptides, DNA, and histones. Neutrophil elastase (NE), matrix metalloproteinase-9, and histone G are the key components of NETs critically involved in breast cancer invasion and migration, which suggests an important role of NETs in tumorigenesis and metastasis. Studies have reported that NETs significantly Read More
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Identification of Mitochondrial-related Characteristic Biomarkers in Osteosarcoma using Bioinformatics and Machine Learning
Authors: Jingyi Hou, Yu Zhang, Ning Yang, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu and Naiqiang ZhuAvailable online: 25 February 2025More LessBackground/Aims Osteosarcoma (OS), a malignant tumor originating in bone or cartilage, primarily affects children and adolescents. Notably, substantial alterations in mitochondrial energy metabolism have been observed in OS; however, the specific contribution of mitochondrial-related genes (MRGs) to OS pathogenesis and prognosis remains unclear. Herein, we identified novel diagnostic biomarkers associated with mit Read More
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Rapid Screening and Effective Rabbit-Derived Fab Antibodies Production Based on Yeast Surface Display
Authors: Weili Shen, Tingting Gong and Changli ShaoAvailable online: 24 February 2025More LessIntroduction/Objective Antibodies have broad applications in various fields, such as biology and medicine. The screening and preparation of highly specific and sensitive antibodies are essential research areas. Several techniques for the preparation of mouse-derived antibodies have been developed, but limited studies on rabbit-derived antibodies with a broader antibody profile and easier humanization are reported. An im Read More
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Evaluation of Carbamazepine and Gabapentin’s Safety and Efficacy in Trigeminal Neuralgia Treatment: A Systematic Review and Meta-Analysis
Authors: Yang Yan, Haitao Shang and Tao HanAvailable online: 24 February 2025More LessAim This study aimed to assess the safety and effectiveness of carbamazepine in treating trigeminal neuralgia in contrast to gabapentin. Hence, a systematic review and meta-analysis of randomised controlled trials had been carried out. Methods The relevant studies were searched in PubMed and filtered according to the inclusion and exclusion criteria. Independently, two reviewers chose the studies, evaluated the quality of th Read More
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UPLC-Q-TOF-MS, Network Pharmacology and Molecular Docking to Reveal the Antidepressant Mechanism of the Different Components of Medicinal and Edible Lilies (Lilium sp. pl)
Authors: Zhaoyang Tan, Linghe Huang, Yanqiu Tian, Sai Jiang, Zhi Wang, Hongping Long, Qiaozhen Tong, Shunxiang Li and Lin JiangAvailable online: 24 February 2025More LessBackground and Objectives To explore the mechanism of action of the differential components of medicinal and edible lilies in treating depression by network pharmacology using UPLC-Q-TOF-MS technology. Methods The chemical composition of medicinal and edible lilies was analyzed, screening for unique medicinal compounds. Searched for depression-related targets. Constructed PPI networks. Performed GO and KEG Read More
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Quercetin Inhibits Ectopic Lesion Formation in Mice by Modulating the MAT2A/PRMT5 Pathway through PPARγ Activation
Authors: Shun Zhang, Yuan-Yuan Zhang, Qiu-Xia Zeng, Li Wang, Kong-Xian Li and Qi ChenAvailable online: 24 February 2025More LessObjective This study aimed to examine the impact of quercetin on a mouse model of endometriosis and elucidate its underlying mechanisms. Methods An endometriosis model was established using C57BL/6 mice, which were divided into three groups: 1) sham group, 2) model group, and 3) model group treated with daily gavage administration of 100 mg/kg/d quercetin. After three weeks, mice were euthanized, and histop Read More
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Exploring the Blueprint of Life: The Innovation in Antibody and Protein Design
Authors: Zhiwei Yang and Gerald H. LushingtonAvailable online: 20 February 2025More LessThe innovation in antibody and protein design highlights the transformation from empirical approaches to sophisticated strategies integrating computational methods and artificial intelligence (AI). Key principles, such as combinatorial, structure-based, consensus, and computational designs, have been pivotal in predicting structures from sequences (in silico design). Advances in tools, like AlphaFold and Rosetta suite, Read More
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Investigation of LncRNA Expression Profiles and Analysis of Immune-Related lncRNA-miRNA-mRNA Networks in Neovascular Age-Related Macular Degeneration
Authors: Liying Qin, Xiang Gao, Xiuhai Lu, Wencai Liu, Jingyi Tian and Gongqiang YuanAvailable online: 12 February 2025More LessIntroduction Age-related Macular Degeneration (AMD) is a predominant cause of blindness in the elderly. The present study is the first to investigate the alteration of lncRNAs and mRNAs in neovascular AMD. Methods Nine patients with neovascular AMD were included in the study. The control group comprised seven patients with epiretinal membranes. RNA sequencing was performed to obtain the differentially expressed mRN Read More
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Therapeutic Potential of Desert Truffles in the Management of Eye Infections: Demystifying the Fact
Available online: 10 February 2025More LessTruffle, an ascomycetous, hypogeous macrofungi, has long been recognized and valued for its therapeutic and dietary properties. Of late, a range of medicinal compounds, such as ergosterol, tuberoside anandamide, polysaccharides, and phenolics exhibiting anti-inflammatory, immunomodulatory, anticancer, antibacterial, and aphrodisiac properties have been identified in truffles. This review provides an updat Read More
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Bingqing Gao Facilitates the Healing Process of Full-Thickness Skin Defects in Rat Wounds by Activating the PI3K/AKT Pathway
Authors: Hong’e Ma, Rui Hu, Jiajun Guo, Xinfu Wang, Xin Liu, Ning Zhang, Ruilong Ren, Danyang Wang and Wenxian ZhangAvailable online: 04 February 2025More LessBackground Trauma, resulting from mechanical factors, entails damage to human tissues or organs. Whether occurring during times of war or peace, trauma is prevalent, particularly skin defects arising from surgery or external injuries. The development and design of effective wound dressings have become paramount. Bingqing Gao(BQG), rooted in Chinese folk medicine, is employed explicitly in trauma treatment bas Read More
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Therapeutic Mechanism of Zhishi Decoction Regulating P38/MAPK Signaling Pathway on Functional Constipation (FC)
Available online: 04 February 2025More LessBackground Zhishi decoction (ZSD) is one of the most common herb decoctions in traditional Chinese medicine (TCM), and it is used for the treatment of FC. However, its main therapeutic mechanism is not yet clear. This study aims to explore the possible pharmacodynamic material basis and potential molecular mechanism from network pharmacology and molecular docking and verify them through animal experim Read More
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CD4+ Effector Memory T Cells Related Marker Gene Signatures in Osteoporosis and Aging: Insight From Single-Cell Analysis and Mendelian Randomization
Authors: Xiangwen Shi, Linmeng Tang, Mingjun Li, Yipeng Wu and Yongqing XuAvailable online: 04 February 2025More LessObjective With the accelerated aging of the population, aging has emerged as a major risk factor for osteoporosis (OP). This study aims to investigate the relationship and shared molecular mechanisms between OP and aging through various genetic approaches. Methods Single-cell data from the peripheral blood of osteoporosis patients, aging individuals, and healthy controls were integrated to analyze characteristic Read More
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A Comparative Chemoinformatics Analysis of Compounds Extracted from Nyctanthes Arbor-tristis
Authors: Nandini Sandeep Kotharkar, Sanket Bapat, Pranav Pathak and Renu VyasAvailable online: 02 February 2025More LessIntroduction Natural products are a rich source of diverse chemical compounds with interesting therapeutic properties. There is a need for in-depth investigation of this reservoir with in-silico tools to assert the molecular diversity with respect to clinical significance. Although studies have been reported on plants such as Nyctanthes arbor-tristis(NAT) and its medicinal importance. A comprehensive study on comparative analysis Read More
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Forsythiaside A Ameliorates Inflammation by Regulating the Autophagy in Methotrexate-induced Intestinal Mucositis
Authors: Wuying Lang, Jiayi Zhang, Xuejun Xiao, Min Cheng, Xin Zheng, Haizhou Gong, Ihsan Ali, Yongping Zhao, Feng Jia, Zhe Wang, Jing Wang, Wei Li and Haihua ZhangAvailable online: 29 January 2025More LessBackground Methotrexate (MTX) effectively eliminates cancerous cells but can also cause inflammation intestinal, known as mucositis. Forsythiaside A (FTA) from Forsythia suspensa has shown promise in relieving mucositis by targeting the NLRP3 pathways. Since NLRP3 inflammasome activation is negatively regulated by autophagy, this study explores how FTA-mediated autophagy affects NLRP3 inflammasome in treating MTX-in Read More
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PGD2/PTGDR2 Signaling Affects the Stemness of Gastric Cancer Stem Cells by Regulating Autophagy
Authors: Feifan Wang, Hengjin Tian, Peiyao Gao, Zhanshan Cha and Qiang ZhangAvailable online: 27 January 2025More LessBackground Prostaglandin D2 (PGD2) can inhibit the development of gastric cancer (GC); however, its role in the autophagic death of GC stem cells (GCSCs) remains elusive. Therefore, this study aims to evaluate the mechanisms by which PGD2 regulates the stemness in GCSCs. Methods In this study, HGC27-derived GCSCs were employed to knock down PGD2 receptor 2 (PTGDR2). Subsequently, cell stemness and autophagic ac Read More
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Predicting Polymerase Chain Reaction Success: Integrating the K-Word Order Model, Physicochemical Properties Modeling of Double Bases, and Support Vector Machine
Available online: 23 January 2025More LessIntroduction Polymerase Chain Reaction (PCR) has been a pivotal scientific technique since the twentieth century, and it is widely applied across various domains. Despite its ubiquity, challenges persist in efficiently amplifying specific DNA templates. Method While PCR experimental procedures have garnered significant attention, the analysis of the DNA template, which is the experiment's focal point, has been notabl Read More
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Investigation of the Mechanism of Pachyman against Gout Arthritis with Network Pharmacology Analysis and Verification In Vivo
Authors: Qing-xin Kong, Wei-ping Xu, Cheng Fan, Bi-Lin Liu, Li-Ping Reng and Qiao RuanAvailable online: 22 January 2025More LessPurpose Pachyman, derived from Poria cocos, has been used to treat gouty arthritis (GA) for thousands of years, although its precise role and mechanisms remain unclear. Herein, we investigate the therapeutic effects of pachyman on GA and explore their underlying mechanisms. Methods Network pharmacology and experimental methods were employed to investigate the therapeutic mechanisms of pachyman against GA. Read More
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Mechanisms of the Compound of Magnoliae Flos and Xanthii Fructus Essential Oils for the Treatment of Allergic Rhinitis based on the Integration of Network Pharmacology, Molecular Docking, and Animal Experiment
Authors: Tao Lu, Yuqin Yang, Zhenlin Yang, Ziyi Liu, Miao Li, Ziman Lu, Ting Gong and Jincheng ZhangAvailable online: 22 January 2025More LessAim and Objective Magnoliae Flos (Chinese name: Xin-Yi) and Xanthii Fructus (Chinese name: Cang-Er-Zi) are Chinese herbal medicines and have been used to treat allergic rhinitis (AR). However, the therapeutic effect, active ingredients, and probable processes of a compound of Magnoliae Flos and Xanthii Fructus in the form of essential oils (CMFXFEO) in treating AR have not been reported. This study aims to determine the Read More
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FOLR1 Regulates the Malignant Progression of Glioblastoma through the SRC/ERK1/2 Axis
Authors: Xueshan Jia, Weihang Liang, Junya Yang, Xuejiao Chen, Bin Yi, Zhikun Cao and Qingfeng TianAvailable online: 20 January 2025More LessBackground GBM is an aggressive brain tumor with limited treatment options. Prior research has indicated FOLR1 as a pivotal gene involved in cancer pathogenesis. Aim This study aimed to explore the involvement of folate receptor alpha (FOLR1) in glioblastoma (GBM) and evaluate its potential as a therapeutic target. Objective This study investigated the expression pattern of FOLR1 in GBM, its impact on patient progno Read More
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Herbal Mucoadhesive Gels for Canker Sores: Analysis of Physicochemical Properties, Efficacy, and Safety
Available online: 20 January 2025More LessAim The goal of this research was to formulate mucoadhesive gels using hydroglyceric extracts of Cistus creticus L. and Inula viscosa (L.) Aiton, either separately or in combination, utilizes carboxymethyl cellulose and detects their physicochemical characteristics and safety for oromucosal cells and antimicrobial (antibacterial, antifungal, and antiviral) efficacy to assess their performance. Methods Using LC-HRMS, the extrac Read More
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Transcriptome-Based Analysis of the Oxidative Response of Thermotoga maritima to the O2 Stress
Authors: Raja Lakhal, Manaf AlMatar, Tahani Alkalaf and Osman AlbarriAvailable online: 16 January 2025More LessBackground Thermotoga maritima is an anaerobic hyperthermophilic eubacterium isolated from geothermally heated maritime surfaces. It can grow at temperatures up to 80 degrees Celsius. Methods A 2.3-L bioreactor was specifically designed to cultivate hyperthermophilic bacteria under carefully regulated pH, redox potential, temperature, and dissolved O2. Results Using this bioreactor, which was adjusted at 80°C and p Read More
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Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules: Traditional to Modern Approach
Available online: 15 January 2025More LessComputer-Aided Drug Design (CADD) entails designing molecules that could potentially interact with a specific biomolecular target and promising their potential binding. The stereo-arrangement and stereo-selectivity of small molecules (SMs)--based chemotherapeutic agents significantly influence their therapeutic potential and enhance their therapeutic advantages. CADD has been a well-established field for decades, but Read More
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Mechanism Analysis of the Effect of Cordycepin on Colorectal Cancer via Network Pharmacology and Experiment
Authors: Ya Chen, Peng Wang, Mingzhu Zhang, Hao Yang and Beibei LiangAvailable online: 14 January 2025More LessObjective Colorectal Cancer (CRC) has attracted much attention due to its high mortality and morbidity. Cordycepin, also known as 3'-deoxyadenosine (3'-dA), exhibits many biological functions, including antibacterial, anti-inflammatory, antiviral, anti-tumor, and immunomodulatory effects. It has been proven to show anticancer activity in both laboratory research studies and living organisms. However, the molecular Read More
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Mechanism Study on the Regulation of Th1/Th2 in the Treatment of Idiopathic Membranous Nephropathy by Shengyang Yiwei Decoction
Authors: Yuan Wu, Xue-Qin Zhang, Heng-Tong An, Shuai-Jie Wang, Ya-Yun Zhao and Zhi-Qiang ChenAvailable online: 13 January 2025More LessBackground Shengyang Yiwei Decoction showed efficacy in idiopathic membranous nephropathy treatment, and this study aimed to assess the underlying molecular mechanisms. Methods Rats with passive Heymann nephritis were divided into the model group, the Shengyang Yiwei Decoction group, the JAK2 inhibitor group, and the STAT3 inhibitor group. Healthy rats served as the normal control. 24-hour urinary pro Read More
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The Anaphylactic and Anti-allergenic Properties of Shuanghuanglian: A Review
Authors: Xin Jiang, Ji Li, Xiaohui Yao and Hao DingAvailable online: 13 January 2025More LessShuanghuanglian (SHL) and its primary constituents have demonstrated protective effects against allergenic diseases. This review examines the anaphylactic and anti-allergenic activities of SHL and its constituents. We also discuss potential avenues for future research, particularly regarding the expansion of the clinical applications of SHL formulations (oral or nebulized) for the treatment of allergenic disorders. For this review Read More
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Betanin Mitigates Inflammation and Ankle Joint Damage by Subduing the MAPK/NF-κB Pathway in Arthritis Triggered by Type II Collagen in Rats
Authors: Yongxiang He, Shaik Althaf Hussain and Wenjie DaiAvailable online: 13 January 2025More LessBackground: Rheumatoid Arthritis (RA), a chronic inflammatory autoimmune illness, is characterized by synovitis, progressive joint damage, and bone erosion. Even though the potent drugs available contain biologics, several patients fail to react to them or cause hostile effects. Objectives Betanin (BTN), the betacyanin present in the red beetroot, has antioxidant, anti-inflammatory, and apoptotic properties. In this study, w Read More
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Bushen Daozhuo Granules Alleviate Chronic Non-Bacterial Prostatitis in Rats through p38 MAPK and Akt Signaling Pathways Based on Tandem Mass Tag-Based Quantitative Proteomics and Network Pharmacology Analyses
Authors: Dalin Sun, Yuanyuan Liu, Dong Xing, Dandan Wang, Bin Cai, Zhian Tang, Qinglin Hu, Wenjun Ma and Baofang JinAvailable online: 13 January 2025More LessIntroduction The traditional Chinese medicine formula, Bushen Daozhuo Granules (BSDZG), is used to treat chronic non-bacterial prostatitis (CNP) clinically. However, its mechanism of action is unclear. The aim of our study was to determine the effect of BSDZG on CNP and its underlying mechanisms. Methods Male Wistar rats were randomly assigned to control, CNP, and BSDZG groups. CNP was induced using purified pro Read More
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TSPOAP1-AS1: A Novel Biomarker for the Prognosis and Therapeutic Target in Cervical Cancer
Authors: Jinyuan Li, Zhen Ye, Yuhong Gan, Dongbing Li and Yibiao ChenAvailable online: 13 January 2025More LessBackground TSPOAP1 antisense RNA 1 (TSPOAP1-AS1) is a long non-coding RNA (lncRNA) that has received widespread attention in oncology research in recent years. Its role and mechanism in some cancers have gradually been revealed. However, it is not clear what role TSPOAP1-AS1 plays in cervical cancer (CESC). Objective In this study, bioinformatic analysis and experimental validation were carried out to investigat Read More
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Mechanism of Qilong Capsule against Myocardial Ischemia-Reperfusion Injury Based on Network Pharmacology and Experimental Validation
Authors: Lingxu Li, Jingxue Ye, Jiahui Zhou, Zhihui Wang, Ruoyun Li, Min Wang and Guibo SunAvailable online: 10 January 2025More LessIntroduction Qilong capsule (QC) has been used clinically to treat ischemic stroke in China. This study evaluated the therapeutic effects of QC on myocardial ischemia-reperfusion injury (MIRI) and its potential mechanisms. Method The components and candidate targets of QC against MIRI were predicted by network pharmacology via relevant databases such as TCMSP, BATMAN-TCM, GeneCards. The potential mechanisms Read More
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Potential Antibacterial of Leaf Sirih Merah Against Enterococcus Faecalis ATCC 29212 Bacteria
Authors: Trisna Yuliana, Devi Meliani and Dikdik KurniaAvailable online: 10 January 2025More LessBackground Dental root canal failure is a disease caused by gram-positive bacteria, Enterococcus faecalis. The disease is caused by the bacterial cell wall consisting of a peptidoglycan layer that protects the bacteria from internal osmotic pressure. Peptidoglycan biosynthesis includes many enzymes, such as MurA, Penicillin-binding protein (PBP), and SrtA. Herbal plants are a source of bioactive compounds, including antibact Read More
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Causal Association between Arm Fat, Left Leg Fat, and Trunk Fat Masses and Risk of Polycystic Ovarian Syndrome: A Mendelian Randomization Study
Authors: Yuhan Zhang, Wei Zhou, Qiong Su and Qi ChenAvailable online: 09 January 2025More LessBackground Observational studies have reported that arm fat, left leg fat, and trunk fat masses have different effects on polycystic ovarian syndrome (PCOS). However, the causal relationship between them remains unknown. Materials and Methods A two-sample Mendelian randomization (MR) study was conducted by utilizing pooled data from the largest Genome-Wide Association Study (GWAS). Random eff Read More
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miR-507 Acts as a Tumor Suppressor in Renal Cell Carcinoma Cells by Targeting STEAP3
Authors: Gong Xiaobo, Huang Jian, Guo Linjie, Tang Zhe, Zhong Guangjun and Feng YeAvailable online: 09 January 2025More LessIntroduction In recent years, there has been a rise in the incidence of renal cell carcinoma (RCC), with metastatic RCC being a prevalent and significant contributor to mortality. While a regulatory role for microRNAs (miRNAs) in the development and progression of RCC has been recognized, their precise functions, molecular mechanisms, and potential clinical implications remain inadequately elucidated. Hence, th Read More
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Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches
Available online: 07 January 2025More LessThe discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine. Owing to its popularity in folk medicine, it has been the subject of intense pharmacological and che Read More
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Label-Free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization
Authors: Joy Concepcion, Krista Witte, Charles Wartchow, Sae Choo, Danfeng Yao, Henrik Persson, Jing Wei, Pu Li, Bettina Heidecker, Weilei Ma, Ram Varma, Lian-She Zhao, Donald Perillat, Greg Carricato, Michael Recknor, Kevin Du, Huddee Ho, Tim Ellis, Juan Gamez, Michael Howes, Janette Phi-Wilson, Scott Lockard, Robert Zuk and Hong Tan
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