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- Volume 24, Issue 10, 2021
Combinatorial Chemistry & High Throughput Screening - Volume 24, Issue 10, 2021
Volume 24, Issue 10, 2021
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Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles
Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic. Methods: Natural products have emerged as via Read More
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Response Surface Methodology to Optimize the Combination Treatment of Paclitaxel, Bufalin and Cinobufagin for Hepatoma Therapy
Authors: Jinghui Zhang, Chenyan Shu, Xiaojiao Yi, Junfeng Zhu, Xiaoyuan Lian and Yongjiang WuBackground: Hepatoma is a common malignancy in the world with high morbidity and mortality. The treatment of hepatoma is limited by its poor response to many chemotherapeutic agents. Although paclitaxel (PTX) is widely used in clinical chemotherapy, the low sensitivity to hepatoma restricts its application. Combination therapy is a promising approach to resolve this dilemma. Objective: To evaluate the interaction bet Read More
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Identification of an MiRNA-mRNA Regulatory Network in Colorectal Cancer
Authors: Ming-fu Cui, Yuan-yu Wu, Ming-yan Chen, Yang Zhao, Song-yun Han, Rui-jie Wang, Haiyan Zhang and Xue-dong FangBackground: Colorectal cancer (CRC) is the fourth most prevalent cancer in the world. However, the molecular mechanism underlying CRC is largely unknown. Objective: To explore the pathogenic mechanism of CRC and to facilitate better diagnosis and treatment of this disease. Methods: Differentially expressed miRNAs (DEMs) and genes (DEGs) in CRC vs. Control samples from the miRNA expression data in GSE115513 an Read More
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FermatS: A Novel Numerical Representation for Protein Sequence Comparison and DNA-binding Protein Identification
Authors: Yanping Zhang, Ya Gao, Jianwei Ni, Pengcheng Chen and Xiaosheng WangAims: Based on protein sequence information, a simple and effective method was used to analyze protein sequence similarity and predict DNA-binding protein. Background: It is absolutely necessary that we generate computational methods of low complexity to accurate infer protein structure, function, and evolution in the rapidly growing number of molecular biology data available. Objective: It is important to generat Read More
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Network Pharmacology and Molecular Docking Approaches to Investigating the Mechanism of Action of Zanthoxylum bungeanum in the Treatment of Oxidative Stress-induced Diseases
Authors: Rong Zhao, Meng-Meng Zhang, Dan Wang, Wei Peng, Qing Zhang, Jia Liu, Li Ai and Chun-Jie WuBackground: Zanthoxylum bungeanum Maxim., a traditional Chinese herbal medicine, has been reported to possess therapeutic effects on diseases induced by oxidative stress (DOS), such as atherosclerosis and diabetes complication. However, the active components and their related mechanisms are still not systematically reported. Objective: The current study was aimed to explore the main active ingredients and the Read More
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In-silico Analysis of Angiotensin-converting Enzyme 2 (ACE2) of Livestock, Pet and Poultry Animals to Determine its Susceptibility to SARS–CoV- 2 Infection
Authors: Aman Kumar, Anil Panwar, Kanisht Batra, Sachinandan De and Sushila MaanBackground: Novel coronavirus SARS-CoV-2 is responsible for the COVID-19 pandemic. It was first reported in Wuhan, China, in December 2019, and despite the tremendous efforts to control the disease, it has now spread almost all over the world. The interaction of SARSCoV- 2spike protein and its acceptor protein ACE2 is an important issue in determining viral host range and cross-species infection, while the binding capacit Read More
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Biomarker Analysis Based Chemoprofiling of Polyherbal Ayurvedic Formulation Containing Vitis vinifera L. by Validated UPLC-MS/MS Method
Authors: Prerna Goel, Vidhu Aeri, Rikeshwer P. Dewangan and Rehan Abdur RubBackground: Drakshasava is one of the commercial Ayurvedic medicines from India, prepared from grapes and spices. It is believed to address health imbalances and claimed to be beneficial for weakness, bleeding disorders, and various inflammatory diseases. It has been reported to possess pharmacological activities such as diuretic, cardioprotective, and antimicrobial. Being a polyherbal mixture, it faces challenges i Read More
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Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain
Authors: Acharya Balkrishna, Subarna Pokhrel and Anurag VarshneyBackground: SARS-CoV-2 has been shown to bind the host cell ACE2 receptor through its spike protein receptor binding domain (RBD), required for its entry into the host cells. Objective: We have screened phytocompounds from a medicinal herb, Tinospora cordifolia for their capacities to interrupt the viral RBD and host ACE2 interactions. Methods: We employed molecular docking to screen phytocompounds in T. cordifolia Read More
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Volumes & issues
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Volume 28 (2025)
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Volume 27 (2024)
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Volume 26 (2023)
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Volume 25 (2022)
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Volume 24 (2021)
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Volume 23 (2020)
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Volume 22 (2019)
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Volume 21 (2018)
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Volume 20 (2017)
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Volume 19 (2016)
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Volume 18 (2015)
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Volume 17 (2014)
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Volume 16 (2013)
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Volume 15 (2012)
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Volume 14 (2011)
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Volume 13 (2010)
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Volume 12 (2009)
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Volume 11 (2008)
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Volume 10 (2007)
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Volume 9 (2006)
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Volume 8 (2005)
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Volume 7 (2004)
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Volume 6 (2003)
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Volume 5 (2002)
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Volume 4 (2001)
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Volume 3 (2000)
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