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Fe3O4@SiO2@CeO2 as a Potential Nanomagnetic Carrier for Oral Delivery System and Release of Celecoxib
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 25, Issue 11, Sep 2022, p. 1973 - 1984
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- 01 Sep 2022
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Abstract
Aims and Objective: In this study, an attempt was made to synthesize, characterize, and develop many applications of functionalized rare metal oxide nanoparticles. Herein, a new strategy for drug delivery is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of celecoxib. Materials and Methods: Magnetite Fe3O4@SiO2 nanoparticles are synthesized by the sol-gel method. The surface of the hydroxyl groups was extended by treating with cerium nitrate salt; finally, sodium hydroxide was anchored to the surface hydroxyl groups to produce cerium oxidefunctionalized Fe3O4@SiO2@CeO2 magnetic nanoparticles (FSC). The synthesized sample was characterized by FT-IR, FESEM, VSM, TGA, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups. Results: For this purpose, the amount of loading/release of the drug was investigated in different amounts of nanocomposite and pH values. Conclusion: The results of the present investigation indicate that the formulations (mFSC=5 mg, pH=3.3) can be considered as best among various formulations with respect to particle size, entrapment efficiency, and in-vitro successful drug release.