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Background: The valency of an atom in a molecular structure is the number of its neighboring atoms. A large number of valency based molecular invariants have been conceived, which correlate certain physio-chemical properties like boiling point, stability, strain energy and many more chemical compounds. Objective: Our aim is to study the valency based molecular invariants for four hexa chemical structures, namely hexagonal network, honeycomb network, oxide network and silicate sheet network. Methods: We use the technique of atom-bonds partition according to the valences of atoms to find results. Results and Conclusion: Exact values of valency-based molecular invariants, namely the Randi index, atom bond connectivity index, geometric arithmetic index, harmonic index, Zagreb indices, Zagreb polynomials, F-index and F-polynomial, are found for four hexa chemical structures.