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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 16, Issue 9, Nov 2013, p. 758 - 761
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- 01 Nov 2013
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Abstract
An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
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