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Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 16, Issue 5, Jun 2013, p. 345 - 393
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- 01 Jun 2013
Abstract
The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.
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