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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 16, Issue 10, Dec 2013, p. 840 - 844
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- 01 Dec 2013
Abstract
A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.
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