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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Expeditious Solvent-Free Synthesis of Chromene Derivatives via Three- Component Reactions of N-Nucleophiles
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 15, Issue 10, Dec 2012, p. 835 - 839
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- 01 Dec 2012
Abstract
Multicomponent reactions involving 4-hydroxycumarine, activated acetylenic compounds and N-nucleophiles under solvent-free conditions were investigated. The reactions could also be extended to quinoline or CH-acides. Substituted chromen could be obtained from this routine, which may have potential applications in drugs fields.
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