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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 15, Issue 7, Aug 2012, p. 571 - 575
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- 01 Aug 2012
Abstract
Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives in the presence of activated acetylenes at 80o C. No additional solvent and catalyst are required.
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