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2000
Volume 15, Issue 5
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

A novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.

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/content/journals/cchts/10.2174/138620712800194521
2012-06-01
2025-07-12
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