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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 14, Issue 7, Aug 2011, p. 570 - 582
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- 01 Aug 2011
Abstract
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
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