Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences

Abdelaziz El Maatougui; Abel Crespo; Artur M.S. Silva; Alberto Coelho

doi:10.2174/138620711796367229

ISSN: 1386-2073
E-ISSN: 1875-5402

Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences
By Abdelaziz El Maatougui, Abel Crespo, Artur M.S. Silva and Alberto Coelho
Source: Combinatorial Chemistry & High Throughput Screening, Volume 14, Issue 7, Aug 2011, p. 570 - 582
DOI: https://doi.org/10.2174/138620711796367229
- Available online: 01 Aug 2011

Abstract

An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.

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2011-08-01

2025-06-16

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Article Type: Research Article

Keyword(s): alkyl halides; Alkylation; Aza-Michael; high atom economy; Knoevenagel; methylene compounds; polymer supported superbases; solution phase synthesis; structural diversification; synthetic organic chemistry; TBD; TBD-Assisted

Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences

Abstract

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