Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Scott S. Woodard; Kevin D. Jerome

doi:10.2174/138620711794474033

ISSN: 1386-2073
E-ISSN: 1875-5402

Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles
By Scott S. Woodard and Kevin D. Jerome
Source: Combinatorial Chemistry & High Throughput Screening, Volume 14, Issue 2, Feb 2011, p. 132 - 137
DOI: https://doi.org/10.2174/138620711794474033
- Available online: 01 Feb 2011

Abstract

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles.

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2011-02-01

2025-07-25

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Article Type: Research Article

Keyword(s): 1,2,4-triazoles; acetonitrile; Amberlyst A-21; Benzyl imidate; combinatorial chemistry; Cyclizations; H NMR; hydrazides; imidates; Isovaleroic hydrazide; Methyl imidate HCl; Pinner reaction

Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Abstract

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