Skip to content
2000
Volume 12, Issue 2
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

The operating principles and some applications of atmospheric pressure desorption electrospray ionization (DESI) and surface activated chemical ionization (SACI) methods are described in detail. The former technique allows one to obtain information on the chemical composition (in terms of organic compounds) present on a surface of interest. The latter, SACI, provides chemical information as a result of the interaction of a vaporised solution of the analyte with a metallic surface. Both techniques typically lead to the production of abundant protonated molecules. The data available in the literature indicate that both DESI and SACI are highly promising techniques with the former giving to mass spectrometry new application fields, and the latter an increasing sensitivity and a lowering of chemical noise that, in the case of biological samples, represent a weak point in many analytical measurements.

Loading

Article metrics loading...

/content/journals/cchts/10.2174/138620709787315427
2009-02-01
2025-07-03
Loading full text...

Full text loading...

/content/journals/cchts/10.2174/138620709787315427
Loading

  • Article Type:
    Research Article
Keyword(s): DESI; drugs; peptides; SACI
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test