Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Marine Peuchmaur; Yung-Sing Wong

doi:10.2174/138620708785739916

ISSN: 1386-2073
E-ISSN: 1875-5402

Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis
Authors: Marine Peuchmaur¹ and Yung-Sing Wong²
View Affiliations Hide Affiliations

¹ Departement de Pharmacochimie Moleculaire, Universite de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Batiment E, Batiment E, Batiment Andre Rassat, 470 rue de la Chimie, 38 041 Grenoble Cedex 9, France. ² Departement de Pharmacochimie Moleculaire, Universite de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Batiment E, Batiment E, Batiment Andre Rassat, 470 rue de la Chimie, 38 041 Grenoble Cedex 9, France.
Source: Combinatorial Chemistry & High Throughput Screening, Volume 11, Issue 8, Sep 2008, p. 587 - 601
DOI: https://doi.org/10.2174/138620708785739916
- Available online: 01 Sep 2008

Abstract

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

Article metrics loading...

/content/journals/cchts/10.2174/138620708785739916

2008-09-01

2025-04-16

From This Site

/content/journals/cchts/10.2174/138620708785739916

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/cchts/10.2174/138620708785739916

Article Type: Research Article

Keyword(s): chemical space; complexity; diversity; Diversity-Oriented Synthesis; multicomponent reactions; skeletal divergent reactions; small molecules; stereodivergent reactions

Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Privileged Structures: Applications in Drug Discovery

Computational Methods in Developing Quantitative Structure-Activity Relationships (QSAR): A Review

Recent Advances on Potentiometric Membrane Sensors for Pharmaceutical Analysis

Label-Free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization

Metalloproteinase Inhibitors for the Disintegrin-Like Metalloproteinases ADAM10 and ADAM17 that Differentially Block Constitutive and Phorbol Ester-Inducible Shedding of Cell Surface Molecules

On Various Metrics Used for Validation of Predictive QSAR Models with Applications in Virtual Screening and Focused Library Design

Diversity Among Microbial Cyclic Lipopeptides: Iturins and Surfactins. Activity-Structure Relationships to Design New Bioactive Agents

Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

Peptidomics The Comprehensive Analysis of Peptides in Complex Biological Mixtures

Molecular Mechanisms of Membrane Perturbation by Antimicrobial Peptides and the Use of Biophysical Studies in the Design of Novel Peptide Antibiotics