Skip to content
2000
Volume 11, Issue 5
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

G protein-coupled receptors (GPCRs) have been proven to be the largest family of druggable targets in the human genome. Given the importance of GPCRs as drug targets and the de-orphanization of novel targets, GPCRs are likely to remain the frequent targets of many drug discovery programs. With recent advances in instrumentation and understanding of cellular mechanisms for the signals measured, biosensor-centered label-free cell assay technologies become a very active area for GPCR screening. This article reviews the principles and potential of current label-free cell assay technologies in GPCR drug discovery.

Loading

Article metrics loading...

/content/journals/cchts/10.2174/138620708784534789
2008-06-01
2025-07-12
Loading full text...

Full text loading...

/content/journals/cchts/10.2174/138620708784534789
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test