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2000
Volume 10, Issue 6
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

The complexation of norfloxacin (NFLX) by p-sulfonated calix[4]arene (SC4A) in aqueous solution has been studied by fluorescence spectroscopy and 1H NMR spectroscopy. A 1:1 stoichiometry and a 8086 L mol-1 stability constant of the NFLX-SC4A complex was obtained by spectrofluorometric titrations. The equimolar solid state inclusion complex of NFLX-SC4A was prepared by the co-precipitation method and then characterized by various techniques, including differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), Fourier-transform infrared analysis (FT-IR) and scanning electron microscopy (SEM). The experimental results of these chemical property screenings confirmed that NFLX and SC4A can form a stable host-guest complex in the solid state, and SC4A appears to function as a complexing and solubilizing agent for NFLX.

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/content/journals/cchts/10.2174/138620707781996448
2007-07-01
2025-07-11
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/content/journals/cchts/10.2174/138620707781996448
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  • Article Type:
    Research Article
Keyword(s): norfloxacin; p-Sulfonated calix[4]arene; solid inclusion complex
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