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As Combinatorial Chemistry & High Throughput Screening begins its tenth year of publication, I would like to look back at some of the highlights of these last ten years. The initial effort to organize this journal was carried out in 1997 by John M. Pezzuto, when he was my colleague here at the University of Illinois, Chicago. Due to a wealth of other commitments, John Pezzuto stepped down from his role as the founding editor of the journal, and I accepted the position as Editor-in-Chief. Today, John Pezzuto is on the Editorial Board of CCHTS and is Professor and founding Dean of the College of Pharmacy of the University of Hawaii. The first issue of CCHTS, consisting of four issues, appeared in 1998. The next year, the publication frequency was increased from four to six issues per year. Due to the worldwide growth of research in combinatorial chemistry and high throughput screening, the publication frequency of CCHTS was increased again to eight issues when volume 4 was published in 2001. At eight issues per year, CCHTS became the leader in this field. By 2006, the large number of papers in the publication queue prompted us to expand volume 9 to 10 issues per year, which established a new standard. The benefit of frequent publication is that CCHTS has minimal time between paper acceptance and publication. From its inception, CCHTS has occupied a unique position in the peer reviewed literature by focusing on the publication of review articles and original research papers in combinatorial chemistry, high throughput screening, and the interface of these related fields. To the best of my knowledge, no other journal specializes in this combination of topics. In addition, the editorial policy of CCHTS has always been to publish papers in all areas of combinatorial chemistry and high-throughput screening, and this policy will continue with volume 10. For example, readers of CCHTS this year should expect to see papers ranging from the use of high throughput screening for the optimization of solid-phase catalysts for different chemical reactions (see this issue) to combinatorial library synthesis using multicomponent reactions. A reflection of the breadth of the readership of CCHTS is the citation of papers published in this journal. Please note the ten most cited papers appearing to date in CCHTS, which are cited in order below [1-10]. Approximately half of these papers concern combinatorial chemistry, such as combinatorial chemical synthesis or computational rational design of combinatorial libraries, and the other half of these highly cited papers address high throughput screening methods and applications, such as the application of fluorescence polarization to HTS or virtual screening of combinatorial libraries. I would like to congratulate the corresponding author Peter Schulz-Knappe and his colleagues for contributing the most highly cited paper so far to CCHTS [1]. In this paper, the term, “peptidomics”, was coined, which is defined as the process of analyzing and visualizing peptides and small proteins from biological samples. In addition, I would like to acknowledge Reto Crameri who served as the guest editor for the special issue in which this peptidomics paper appeared. As in the past, regular issues of CCHTS will be alternated with special issues focusing on a single topic of current interest. Some of these special issues will be organized by members of our Editorial Board and others will be organized by guest editors who will introduce fresh perspectives and unique expertise to the journal. Readers should note that all papers published in CCHTS are peer reviewed whether they appear in a special issue on a hot topic or in a regular issue. Papers published in CCHTS receive high visibility, since they are abstracted and indexed by the major services including Chemical Abstracts, BIOSIS, CAB Abstracts, EMBASE, BIOBASE, Science Citation Index-Expanded, MEDLINE, and Current Contents (Life Sciences). Through the combination of frequent publication, peer review and high visibility, Combinatorial Chemistry & High Throughput Screening remains a unique and essential scientific journal defining the intersection of the interdependent disciplines of combinatorial chemistry and HTS. I would like to thank the distinguished members of the Editorial Board, the Regional Editors, the guest editors, the authors, and of course you, the readers, for the continuing success of our journal. The 10 most cited papers appearing in Combinatorial Chemistry & High Throughput Screening from 1998 to 2006 (according to the Web-of-Science, produced by Thomson Scientific, Philadelphia, PA; accessed on-line January 4, 2007 at http://scientific.thompson.com)..