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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 8, Issue 5, Aug 2005, p. 439 - 443
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- 01 Aug 2005
Abstract
selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.
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