Skip to content
2000
Volume 7, Issue 4
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Lead identification and optimisation have evolved into multidimensional, multidisciplinary and information-driven processes. Herein, we review the contribution of computational chemistry to these processes. We focus on computational approaches developed for modelling biopharmaceutical properties, including in vitro activity, selectivity, absorption, distribution, metabolism, excretion and toxicity. Whenever possible, successful applications are mentioned.

Loading

Article metrics loading...

/content/journals/cchts/10.2174/1386207043328643
2004-06-01
2025-07-09
Loading full text...

Full text loading...

/content/journals/cchts/10.2174/1386207043328643
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test