Full text loading...
- ISSN: 1386-2073
- E-ISSN: 1875-5402
-
Solid-Phase and Solution-Phase Parallel Synthesis of Tetrahydro-isoquinolines via Pictet-Spengler Reaction
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Issue 1, Feb 2002, p. 75 - 81
-
- 01 Feb 2002
Abstract
An efficient parallel synthesis of 6,7-dimethoxytetrahydroisoquinolines is reported. The key reaction step is 3,4-dimethoxyphenethylimines reacting with acid chlorides to form an N-acyliminium ion intermediate, which undergoes Pictet-Spengler condensation to give the desired products in >80 percent yield. Both solution-phase and solid-phase synthesis of 6,7-dimethoxytetrahydroisoquinolines are described.
© Bentham Science Publishers