Alkylaminopropenones and Alkylamino-Propenoates as Efficient and Versatile Synthons in Microwave-Assisted Combinatorial Synthesis

A simple and fast one-pot method using microwave irradiation for the synthesis of a number of small libraries of diverse heterocycles is described in this paper. The two-step one-pot method includes the formation of alkylaminopropenones or alkylaminopropenoates in 5 min at 180 °C and a subsequent treatment with dinucleophiles for 3 to 5 min at 150 °C to 180 °C to form a variety of biologically interesting heterocycles in a cascade-type reaction. The combination of combinatorial chemistry and microwave-assisted synthesis was found to be very efficient.